Acetylsalicylic acid reduces pH-induced excitation of rat cutaneous nociceptors in vitro

Acetylsalicylic acid reduces pH-induced excitation of rat cutaneous nociceptors in vitro Prim. Sensory Neuron , Vol. 2, No. 2, pp. 77 – 94 (1997) Ó VSP 1997. Acetylsalicylic acid reduces pH-induced excitation of rat cutaneous nociceptors in vitro DIMITRIOS STEFANIDIS, 1 PETER W. REEH 2 and KAY H. STEEN 1 , ∗ 1 Universita¨ ts-Hautklinik und Poliklinik der Universita¨ t Bonn , Klinische Dermatophysiologie , Sigmund-Freud-Straße 25 , D-53105 Bonn , Germany 2 Institut fu¨ r Physiologie und Experimentelle Pathophysiologie der Universita¨ t Erlangen-Nu¨ rnberg , Universita¨ tsstraße 17 , D-91054 Erlangen , Germany Received 29 April 1996; accepted 2 December 1996 Abstract —The effects of acetylsalicylic acid (ASA) and of salicylic acid (SA) on pH-induced nociceptor excitation were investigated in a rat skin-saphenous nerve preparation in vitro , where isolated receptive fields of identified single nerve fibers were superfused at the corium side with controlled solutions to test their chemosensitivity. A total of 133 unmyelinated mechano-heat-sensitive (‘polymodal’) C-fibers were superfused with an acidic solution (CO 2 -saturated synthetic interstitial fluid; pH 6.1) for at least 10 min. If fibers responded to the acid pH ( n = 89; 67%), ASA or SA was added after 10 min for a 10 min period in various concentrations (ASA: 10 − http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Primary Sensory Neuron Brill

Acetylsalicylic acid reduces pH-induced excitation of rat cutaneous nociceptors in vitro

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Publisher
Brill
Copyright
© 1997 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0929-9637
eISSN
1879-5323
DOI
10.1163/092996397750131892
Publisher site
See Article on Publisher Site

Abstract

Prim. Sensory Neuron , Vol. 2, No. 2, pp. 77 – 94 (1997) Ó VSP 1997. Acetylsalicylic acid reduces pH-induced excitation of rat cutaneous nociceptors in vitro DIMITRIOS STEFANIDIS, 1 PETER W. REEH 2 and KAY H. STEEN 1 , ∗ 1 Universita¨ ts-Hautklinik und Poliklinik der Universita¨ t Bonn , Klinische Dermatophysiologie , Sigmund-Freud-Straße 25 , D-53105 Bonn , Germany 2 Institut fu¨ r Physiologie und Experimentelle Pathophysiologie der Universita¨ t Erlangen-Nu¨ rnberg , Universita¨ tsstraße 17 , D-91054 Erlangen , Germany Received 29 April 1996; accepted 2 December 1996 Abstract —The effects of acetylsalicylic acid (ASA) and of salicylic acid (SA) on pH-induced nociceptor excitation were investigated in a rat skin-saphenous nerve preparation in vitro , where isolated receptive fields of identified single nerve fibers were superfused at the corium side with controlled solutions to test their chemosensitivity. A total of 133 unmyelinated mechano-heat-sensitive (‘polymodal’) C-fibers were superfused with an acidic solution (CO 2 -saturated synthetic interstitial fluid; pH 6.1) for at least 10 min. If fibers responded to the acid pH ( n = 89; 67%), ASA or SA was added after 10 min for a 10 min period in various concentrations (ASA: 10 −

Journal

Primary Sensory NeuronBrill

Published: Jan 1, 1997

Keywords: Skin; sensory; nerve endings; hydrogen ions; salicylic acid; aspirin; protons

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