Prim. Sensory Neuron , Vol. 2, No. 2, pp. 77 – 94 (1997) Ó VSP 1997. Acetylsalicylic acid reduces pH-induced excitation of rat cutaneous nociceptors in vitro DIMITRIOS STEFANIDIS, 1 PETER W. REEH 2 and KAY H. STEEN 1 , ∗ 1 Universita¨ ts-Hautklinik und Poliklinik der Universita¨ t Bonn , Klinische Dermatophysiologie , Sigmund-Freud-Straße 25 , D-53105 Bonn , Germany 2 Institut fu¨ r Physiologie und Experimentelle Pathophysiologie der Universita¨ t Erlangen-Nu¨ rnberg , Universita¨ tsstraße 17 , D-91054 Erlangen , Germany Received 29 April 1996; accepted 2 December 1996 Abstract —The effects of acetylsalicylic acid (ASA) and of salicylic acid (SA) on pH-induced nociceptor excitation were investigated in a rat skin-saphenous nerve preparation in vitro , where isolated receptive fields of identified single nerve fibers were superfused at the corium side with controlled solutions to test their chemosensitivity. A total of 133 unmyelinated mechano-heat-sensitive (‘polymodal’) C-fibers were superfused with an acidic solution (CO 2 -saturated synthetic interstitial fluid; pH 6.1) for at least 10 min. If fibers responded to the acid pH ( n = 89; 67%), ASA or SA was added after 10 min for a 10 min period in various concentrations (ASA: 10 −
Primary Sensory Neuron – Brill
Published: Jan 1, 1997
Keywords: Skin; sensory; nerve endings; hydrogen ions; salicylic acid; aspirin; protons
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera