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Thyrotrophin gene regulation

Thyrotrophin gene regulation Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham b15 2threceived 1 November 1987IntroductionThyrotrophin (TSH) is one of a family of glycoprotein hormones which includes the pituitary hormones follicle-stimulating hormone and luteinizing hormone, and placental chorionic gonadotrophin. Each hormone is composed of two dissimilar, non-covalently linked glycosylated subunits, α and β. The mammalian genome contains a single gene encoding the α-subunit which is common to each of the glycoprotein hormones (Fiddes & Goodman, 1981). In contrast, the β-subunits of each hormone are encoded by different genes and confer biological and immunological specificity upon the intact dimer.The gene encoding the β-subunit of TSH has been assigned to chromosome 1 in man (Fukushige, Murotsu & Matsubara, 1986) and chromosome 3 in the mouse (Kourides, Barker, Gurr et al. 1984). The α-gene, unlike the β-gene, has been assigned in the mouse to chromosome 4 (Kourides et al. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

Thyrotrophin gene regulation

Franklyn, J. A.; Sheppard, M. C.
Journal of Endocrinology , Volume 117 (2) – May 1, 1988
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Publisher
Bioscientifica
Copyright
Copyright © 1988 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.1170161
Publisher site
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Abstract

Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham b15 2threceived 1 November 1987IntroductionThyrotrophin (TSH) is one of a family of glycoprotein hormones which includes the pituitary hormones follicle-stimulating hormone and luteinizing hormone, and placental chorionic gonadotrophin. Each hormone is composed of two dissimilar, non-covalently linked glycosylated subunits, α and β. The mammalian genome contains a single gene encoding the α-subunit which is common to each of the glycoprotein hormones (Fiddes & Goodman, 1981). In contrast, the β-subunits of each hormone are encoded by different genes and confer biological and immunological specificity upon the intact dimer.The gene encoding the β-subunit of TSH has been assigned to chromosome 1 in man (Fukushige, Murotsu & Matsubara, 1986) and chromosome 3 in the mouse (Kourides, Barker, Gurr et al. 1984). The α-gene, unlike the β-gene, has been assigned in the mouse to chromosome 4 (Kourides et al.

Journal

Journal of Endocrinology – Bioscientifica

Published: May 1, 1988

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