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- Publisher
- Bioscientifica
- Copyright
- Copyright © 1966 The Authors. All Rights Reserved.
- ISSN
- 0022-0795
- eISSN
- 1479-6805
- DOI
- 10.1677/joe.0.0350223
- Publisher site
- See Article on Publisher Site
Abstract
SUMMARYSerum tyrosine was measured in 22 normal subjects, 17 patients with non-toxic goitre, ten patients with hypothyroidism, 37 patients with thyrotoxicosis and eight geriatric patients. Low values were obtained in hypothyroidism and high values in thyrotoxicosis. In thyrotoxicosis there was only a small overlap with the euthyroid subjects. Thus, measurements of serum tyrosine appear to be a useful test for the diagnosis of hyperthyroidism, not invalidated by previous iodine administration and not involving the use of radio-isotopes. Administration of vitamin C reduced the increased values of tyrosine in thyrotoxicosis to normal levels. It is suggested that a latent vitamin C deficiency may partly explain the increase in the serum tyrosine values in thyrotoxicosis.
Journal
Journal of Endocrinology – Bioscientifica
Published: Jul 1, 1966