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/lp/bioscientifica/the-effect-of-a-high-fat-diet-on-glucose-insulin-sensitivity-and-S8SdphPwjC
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- Publisher
- Bioscientifica
- Copyright
- Copyright © 1968 The Authors. All Rights Reserved.
- ISSN
- 0022-0795
- eISSN
- 1479-6805
- DOI
- 10.1677/joe.0.0420489
- Publisher site
- See Article on Publisher Site
Abstract
SUMMARYThe influence of the diet on the levels of insulin was studied in rats on a high-fat diet. Plasma and glucose insulin concentrations of a control group and of rats on a high-fat diet were compared, and so was the insulin concentration in the pancreas of the two groups.The mean plasma insulin concentration in the control group was 40 μ-u./ml. and that of insulin extracted from the pancreas was 2·5 μg./100 mg. tissue; plasma glucose was 156 mg./100 ml.The animals fed on a high-fat diet showed diabetic features. The mean plasma insulin level was 9 μ-u./ml., and plasma glucose increased to 210 mg./100 ml. The insulin concentration in the pancreas was not significantly different from that in the controls. In vitro the epididymal fat and the diaphragm of the high-fat-diet group were less sensitive to insulin than the same tissues in the control group.
Journal
Journal of Endocrinology – Bioscientifica
Published: Dec 1, 1968