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TESTICULAR 17-OXOSTEROID SECRETION IN RESPONSE TO HUMAN CHORIONIC GONADOTROPHIN IN DOGS PRETREATED WITH ASPIRIN

TESTICULAR 17-OXOSTEROID SECRETION IN RESPONSE TO HUMAN CHORIONIC GONADOTROPHIN IN DOGS... Department of Pathophysiology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan(Received 8 December 1976)Since it has been reported that prostaglandin synthesis occurs in rat (Ellis, Johnson & Hargrove, 1972; Carpenter, 1974) and rabbit testes (Christ & van Dorp, 1972), we have studied the 17-oxosteroid secretory response of the testis to human chorionic gonadotrophin (HCG) in dogs pretreated with aspirin, a potent inhibitor of prostaglandin synthesis (Vane, 1971).Fourteen male mongrel dogs weighing between 7·8 and 19·8 kg were used. Each animal was anaesthetized by i.v. injection of sodium pentobarbitone (25 mg/kg) and the left spermatic vein was cannulated by the lumbar route (Yamashita, 1966). After spermatic venous cannulation, aspirin (20 or 200 mg/kg) was given with 200 ml distilled water into the stomach through an oesophageal catheter. Controls received 200 ml distilled water only. Three hours after the administration of aspirin, 1 ml 0·9% NaCl solution http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

TESTICULAR 17-OXOSTEROID SECRETION IN RESPONSE TO HUMAN CHORIONIC GONADOTROPHIN IN DOGS PRETREATED WITH ASPIRIN

YAMASHITA, K.; AMANO, A.
Journal of Endocrinology , Volume 73 (3) – Jun 1, 1977
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Publisher
Bioscientifica
Copyright
Copyright © 1977 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0730529
Publisher site
See Article on Publisher Site

Abstract

Department of Pathophysiology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan(Received 8 December 1976)Since it has been reported that prostaglandin synthesis occurs in rat (Ellis, Johnson & Hargrove, 1972; Carpenter, 1974) and rabbit testes (Christ & van Dorp, 1972), we have studied the 17-oxosteroid secretory response of the testis to human chorionic gonadotrophin (HCG) in dogs pretreated with aspirin, a potent inhibitor of prostaglandin synthesis (Vane, 1971).Fourteen male mongrel dogs weighing between 7·8 and 19·8 kg were used. Each animal was anaesthetized by i.v. injection of sodium pentobarbitone (25 mg/kg) and the left spermatic vein was cannulated by the lumbar route (Yamashita, 1966). After spermatic venous cannulation, aspirin (20 or 200 mg/kg) was given with 200 ml distilled water into the stomach through an oesophageal catheter. Controls received 200 ml distilled water only. Three hours after the administration of aspirin, 1 ml 0·9% NaCl solution

Journal

Journal of Endocrinology – Bioscientifica

Published: Jun 1, 1977

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