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STEROID BIOSYNTHESIS BY HUMAN FOETAL ADRENALS INCUBATED IN VITRO WITH [4-14C]PROGESTERONE: CHANGES WITH GESTATIONAL AGE

STEROID BIOSYNTHESIS BY HUMAN FOETAL ADRENALS INCUBATED IN VITRO WITH [4-14C]PROGESTERONE:... SUMMARYAdrenals from foetuses of 13 to 27 weeks gestation were sliced and incubated with 5 μC of [4-14C]progesterone for 2 hr. The biosynthesis of cortisol, 11-deoxycortisol, androstenedione and 11β-hydroxyandrostenedione was estimated by reverse isotope dilution. Cortisol was the major product identified and the production of both cortisol and 11β-hydroxyandrostenedione increased with gestational age in approximate proportion to the increasing adrenal weight. The ratio of (cortisol plus 11-deoxycortisol) to (androstenedione plus 11β-hydroxyandrostenedione) was constant at 13, 16 and 27 weeks gestation. The production of cortisol and androstenedione from progesterone and from pregnenolone by adrenal tissue from a 27-week-old foetus is compared. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

STEROID BIOSYNTHESIS BY HUMAN FOETAL ADRENALS INCUBATED IN VITRO WITH [4-14C]PROGESTERONE: CHANGES WITH GESTATIONAL AGE

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Publisher
Bioscientifica
Copyright
Copyright © 1970 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0470379
Publisher site
See Article on Publisher Site

Abstract

SUMMARYAdrenals from foetuses of 13 to 27 weeks gestation were sliced and incubated with 5 μC of [4-14C]progesterone for 2 hr. The biosynthesis of cortisol, 11-deoxycortisol, androstenedione and 11β-hydroxyandrostenedione was estimated by reverse isotope dilution. Cortisol was the major product identified and the production of both cortisol and 11β-hydroxyandrostenedione increased with gestational age in approximate proportion to the increasing adrenal weight. The ratio of (cortisol plus 11-deoxycortisol) to (androstenedione plus 11β-hydroxyandrostenedione) was constant at 13, 16 and 27 weeks gestation. The production of cortisol and androstenedione from progesterone and from pregnenolone by adrenal tissue from a 27-week-old foetus is compared.

Journal

Journal of Endocrinology – Bioscientifica

Published: Jul 1, 1970

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