Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Serotoninergic inhibition of LH secretion in the domestic fowl

Serotoninergic inhibition of LH secretion in the domestic fowl ABSTRACTImmature cockerels were injected with drugs known to affect serotoninergic activity. The receptor agonist quipazine as well as pargyline, an inhibitor of serotonin breakdown, both reduced plasma LH concentrations in a time-dependent fashion. The effect of pargyline was also dose-related. The serotonin precursor, tryptophan, reduced plasma LH levels. Tryptophan and pargyline were as effective in pubertal cockerels as in 3-week-old birds. Responses to quipazine were attenuated by the antagonist, methysergide, although another antagonist, cyproheptadine, also reduced plasma LH levels. Serotonin itself had no effect on plasma LH levels. Parachlorophenylalanine, which blocks serotonin synthesis, had no effect on plasma LH by itself, but attenuated the tryptophan-induced inhibition of LH. These data indicate that serotoninergic mechanisms inhibit secretion of LH in domestic fowl. This mechanism probably operates through the central nervous system.J. Endocr. (1986) 110, 239–244 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

Serotoninergic inhibition of LH secretion in the domestic fowl

Hall, T. R.; Cheung, A.; Harvey, S.
Journal of Endocrinology , Volume 110 (2) – Aug 1, 1986
Download PDF
6 pages

Loading next page...
 
/lp/bioscientifica/serotoninergic-inhibition-of-lh-secretion-in-the-domestic-fowl-7AdlOkJSU5

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Bioscientifica
Copyright
Copyright © 1986 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.1100239
Publisher site
See Article on Publisher Site

Abstract

ABSTRACTImmature cockerels were injected with drugs known to affect serotoninergic activity. The receptor agonist quipazine as well as pargyline, an inhibitor of serotonin breakdown, both reduced plasma LH concentrations in a time-dependent fashion. The effect of pargyline was also dose-related. The serotonin precursor, tryptophan, reduced plasma LH levels. Tryptophan and pargyline were as effective in pubertal cockerels as in 3-week-old birds. Responses to quipazine were attenuated by the antagonist, methysergide, although another antagonist, cyproheptadine, also reduced plasma LH levels. Serotonin itself had no effect on plasma LH levels. Parachlorophenylalanine, which blocks serotonin synthesis, had no effect on plasma LH by itself, but attenuated the tryptophan-induced inhibition of LH. These data indicate that serotoninergic mechanisms inhibit secretion of LH in domestic fowl. This mechanism probably operates through the central nervous system.J. Endocr. (1986) 110, 239–244

Journal

Journal of Endocrinology – Bioscientifica

Published: Aug 1, 1986

There are no references for this article.