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PROGESTERONE SECRETION BY THE SHEEP CORPUS LUTEUM AFTER REPEATED INFUSIONS OF LUTEINIZING HORMONE AND HUMAN CHORIONIC GONADOTROPHIN

PROGESTERONE SECRETION BY THE SHEEP CORPUS LUTEUM AFTER REPEATED INFUSIONS OF LUTEINIZING HORMONE... SUMMARYThe response of the ovine corpus luteum to repeated infusions of luteinizing hormone (LH) or of human chorionic gonadotrophin (HCG) was tested in four ewes with the left ovary autotransplanted to the neck. Constant infusion for 1 h of either LH (100 or 1000 μg/h) or HCG (200 i.u./h) via the ovarian artery stimulated a temporary increase in secretion of progesterone which fell to control levels by 60 min. Ovarian blood flow increased progressively (P < 0·05) throughout the infusion of gonadotrophin in three of the five experiments. A second infusion of either gonadotrophin after a further control hour failed to stimulate progesterone secretion. These results suggest that ovine luteal tissue rapidly becomes refractory to the steroidogenic effect of LH in vivo. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

PROGESTERONE SECRETION BY THE SHEEP CORPUS LUTEUM AFTER REPEATED INFUSIONS OF LUTEINIZING HORMONE AND HUMAN CHORIONIC GONADOTROPHIN

BAIRD, D. T.; COLLETT, R. A.
Journal of Endocrinology , Volume 57 (2) – May 1, 1973
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Publisher
Bioscientifica
Copyright
Copyright © 1973 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0570299
Publisher site
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Abstract

SUMMARYThe response of the ovine corpus luteum to repeated infusions of luteinizing hormone (LH) or of human chorionic gonadotrophin (HCG) was tested in four ewes with the left ovary autotransplanted to the neck. Constant infusion for 1 h of either LH (100 or 1000 μg/h) or HCG (200 i.u./h) via the ovarian artery stimulated a temporary increase in secretion of progesterone which fell to control levels by 60 min. Ovarian blood flow increased progressively (P < 0·05) throughout the infusion of gonadotrophin in three of the five experiments. A second infusion of either gonadotrophin after a further control hour failed to stimulate progesterone secretion. These results suggest that ovine luteal tissue rapidly becomes refractory to the steroidogenic effect of LH in vivo.

Journal

Journal of Endocrinology – Bioscientifica

Published: May 1, 1973

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