Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Oestrogen metabolism in the endometrium, corpus luteum and ovarian residual tissue of the rabbit

Oestrogen metabolism in the endometrium, corpus luteum and ovarian residual tissue of the rabbit Reproductive tissues (uterine endometrium, corpus luteum and ovarian residual tissues) from pregnant and pseudopregnant rabbits were incubated with equimolar concentrations of [3H]oestrone and [3H]oestrone sulphate (0·375 pmol) to monitor the changes in oestrogen metabolism during the early stages of pregnancy (days 0, and 3–8 post coitum) and to investigate the embyonic effect upon maternal oestrogen metabolism.Oestradiol-17β was the major metabolite formed from oestrone and sulphoconjugation occurred in all tissues studied. Oestrone sulphate was converted primarily to oestradiol-17β-3-monosulphate. Endometrial 17β-oxidoreductase significantly decreased and sulpho-transferase increased in activity during the preimplantation period, but no differences were noted between gravid and non-gravid horns in unilaterally pregnant animals, nor between pregnant or pseudopregnant animals. Significant decreases occurred in 17β-oxidoreductase and sulphotransferase activity in luteal tissue, but these were more than offset by increases in tissue weight. No differences in the activities in luteal tissues were detected between pregnant or pseudopregnant animals, nor between ovarian tissue adjacent to gravid or non-gravid uterine horns.The results show that significant changes occur in oestrogen metabolism in the rabbit endometrium and corpus luteum within 8 days after ovulation, and that these changes result from maternal factors expressed systemically rather than by the effects of the developing conceptus expressed locally. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

Oestrogen metabolism in the endometrium, corpus luteum and ovarian residual tissue of the rabbit

Download PDF
13 pages

Loading next page...
 
/lp/bioscientifica/oestrogen-metabolism-in-the-endometrium-corpus-luteum-and-ovarian-pnzoi9fxwy

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Bioscientifica
Copyright
Copyright © 1983 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0960201
Publisher site
See Article on Publisher Site

Abstract

Reproductive tissues (uterine endometrium, corpus luteum and ovarian residual tissues) from pregnant and pseudopregnant rabbits were incubated with equimolar concentrations of [3H]oestrone and [3H]oestrone sulphate (0·375 pmol) to monitor the changes in oestrogen metabolism during the early stages of pregnancy (days 0, and 3–8 post coitum) and to investigate the embyonic effect upon maternal oestrogen metabolism.Oestradiol-17β was the major metabolite formed from oestrone and sulphoconjugation occurred in all tissues studied. Oestrone sulphate was converted primarily to oestradiol-17β-3-monosulphate. Endometrial 17β-oxidoreductase significantly decreased and sulpho-transferase increased in activity during the preimplantation period, but no differences were noted between gravid and non-gravid horns in unilaterally pregnant animals, nor between pregnant or pseudopregnant animals. Significant decreases occurred in 17β-oxidoreductase and sulphotransferase activity in luteal tissue, but these were more than offset by increases in tissue weight. No differences in the activities in luteal tissues were detected between pregnant or pseudopregnant animals, nor between ovarian tissue adjacent to gravid or non-gravid uterine horns.The results show that significant changes occur in oestrogen metabolism in the rabbit endometrium and corpus luteum within 8 days after ovulation, and that these changes result from maternal factors expressed systemically rather than by the effects of the developing conceptus expressed locally.

Journal

Journal of Endocrinology – Bioscientifica

Published: Feb 1, 1983

There are no references for this article.