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INTERACTION OF MORPHINE AND HYPOGLYCAEMIA IN STIMULATING THE RELEASE OF GROWTH HORMONE IN THE RAT

INTERACTION OF MORPHINE AND HYPOGLYCAEMIA IN STIMULATING THE RELEASE OF GROWTH HORMONE IN THE RAT Unité de Neuroendocrinologie, INSERM – U.159, 2ter rue d'Alésia, 75014 Paris, France(Received 16 February 1977)It has been reported by Kokka, Garcia, George & Elliott (1972) and Martin, Audet & Saunders (1975) that morphine stimulates the release of growth hormone (GH) in the rat. Previous studies from this laboratory indicated that another narcoanalgesic, gamma-hydroxybutyrate (GHB), is able to stimulate immunoreactive GH secretion, but the pattern of this response differs markedly from that elicited by morphine (M. T. Bluet-Pajot & C. Schaub, unpublished results). We have also used GHB and eliminated stress effects to demonstrate that GH secretion in the rat can be induced by controlled hypoglycaemia as in primates (Bluet-Pajot, Schaub & Nassiet, 1976).In the present study we have investigated whether morphine could elicit a GH response under GHB narcoanalgesia, and whether GH secretion induced by spontaneous or provoked hypoglycaemia interfered with this effect.Automated blood glucose monitoring http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

INTERACTION OF MORPHINE AND HYPOGLYCAEMIA IN STIMULATING THE RELEASE OF GROWTH HORMONE IN THE RAT

BLUET-PAJOT, M. T.; SCHAUB, C.
Journal of Endocrinology , Volume 74 (2) – Aug 1, 1977
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Publisher
Bioscientifica
Copyright
Copyright © 1977 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0740335
Publisher site
See Article on Publisher Site

Abstract

Unité de Neuroendocrinologie, INSERM – U.159, 2ter rue d'Alésia, 75014 Paris, France(Received 16 February 1977)It has been reported by Kokka, Garcia, George & Elliott (1972) and Martin, Audet & Saunders (1975) that morphine stimulates the release of growth hormone (GH) in the rat. Previous studies from this laboratory indicated that another narcoanalgesic, gamma-hydroxybutyrate (GHB), is able to stimulate immunoreactive GH secretion, but the pattern of this response differs markedly from that elicited by morphine (M. T. Bluet-Pajot & C. Schaub, unpublished results). We have also used GHB and eliminated stress effects to demonstrate that GH secretion in the rat can be induced by controlled hypoglycaemia as in primates (Bluet-Pajot, Schaub & Nassiet, 1976).In the present study we have investigated whether morphine could elicit a GH response under GHB narcoanalgesia, and whether GH secretion induced by spontaneous or provoked hypoglycaemia interfered with this effect.Automated blood glucose monitoring

Journal

Journal of Endocrinology – Bioscientifica

Published: Aug 1, 1977

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