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INSULIN RELEASE FROM THE PERFUSED RAT PANCREAS, STIMULATED BY PERIFUSATES OF THE PITUITARY NEUROINTERMEDIATE LOBES OF GENETICALLY OBESE AND LEAN MICE

INSULIN RELEASE FROM THE PERFUSED RAT PANCREAS, STIMULATED BY PERIFUSATES OF THE PITUITARY... The perfused rat pancreas has been used to study the dynamics of insulin release during stimulation with a perifusate of the pituitary neurointermediate lobe (NIP) of genetically obese mice (ob/ob) and their lean litter-mates (+/+). It has been shown that the NIP of ob/ob mice is more active. The remainder of the study was carried out with NIP from ob/ob mice. The results showed that both phases of insulin release stimulated by 16·6 mm-glucose were increased by NIP. When the pancreas was first stimulated with NIP in the presence of 5·5 mm-glucose, followed by a high concentration of glucose, it responded to the latter with a normal biphasic response. If, however, the pancreas was stimulated first with glucose the response to NIP was refractory.The results are discussed in relation to the possible significance of an insulin secretagogue from the pituitary pars intermedia in the hyperinsulinaemia associated with obesity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

INSULIN RELEASE FROM THE PERFUSED RAT PANCREAS, STIMULATED BY PERIFUSATES OF THE PITUITARY NEUROINTERMEDIATE LOBES OF GENETICALLY OBESE AND LEAN MICE

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Publisher
Bioscientifica
Copyright
Copyright © 1982 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0920015
Publisher site
See Article on Publisher Site

Abstract

The perfused rat pancreas has been used to study the dynamics of insulin release during stimulation with a perifusate of the pituitary neurointermediate lobe (NIP) of genetically obese mice (ob/ob) and their lean litter-mates (+/+). It has been shown that the NIP of ob/ob mice is more active. The remainder of the study was carried out with NIP from ob/ob mice. The results showed that both phases of insulin release stimulated by 16·6 mm-glucose were increased by NIP. When the pancreas was first stimulated with NIP in the presence of 5·5 mm-glucose, followed by a high concentration of glucose, it responded to the latter with a normal biphasic response. If, however, the pancreas was stimulated first with glucose the response to NIP was refractory.The results are discussed in relation to the possible significance of an insulin secretagogue from the pituitary pars intermedia in the hyperinsulinaemia associated with obesity.

Journal

Journal of Endocrinology – Bioscientifica

Published: Jan 1, 1982

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