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INHIBITION BY RESERPINE OF HISTOLOGICAL CHANGES INDUCED BY HYPERTONIC SALINE IN THE HYPOTHALAMIC NEUROSECRETORY SYSTEM OF THE MUSK SHREW, SUNCUS MURINUS L.

INHIBITION BY RESERPINE OF HISTOLOGICAL CHANGES INDUCED BY HYPERTONIC SALINE IN THE HYPOTHALAMIC... It is well established that administration of hypertonic saline brings about characteristic histological changes in the hypothalamic neurosecretory system (HNS), which are regarded as morphological manifestations of augmented secretion of the anti-diuretic hormone (ADH) (see Gabe, 1966). Reserpine is reported to stimulate (Chaudhury, Chaudhury & Lu, 1962; Guzek & Leśnik, 1968), inhibit (Moses, 1964; Bridges & Thorn, 1970), or to have no effect (Boris & Stevenson, 1967) on ADH secretion. The amount of neurosecretory material (NSM) after reserpine treatment has been found to be unchanged (Eränkö, Hopsa, Kivalo & Telkkä, 1957) or diminished (e.g. Gabe, Tuchmann-Duplessis & Mercier-Parot, 1961). The present study reports the effect of reserpine on the histology of the HNS of the musk shrew after treatment with hypertonic saline.Animals were divided into six groups with 12 adults of either sex in each, and treated as follows: Group I: 3% NaCl solution (2 ml/day, i.p.) for 3–5 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

INHIBITION BY RESERPINE OF HISTOLOGICAL CHANGES INDUCED BY HYPERTONIC SALINE IN THE HYPOTHALAMIC NEUROSECRETORY SYSTEM OF THE MUSK SHREW, SUNCUS MURINUS L.

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Publisher
Bioscientifica
Copyright
Copyright © 1971 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0500707
Publisher site
See Article on Publisher Site

Abstract

It is well established that administration of hypertonic saline brings about characteristic histological changes in the hypothalamic neurosecretory system (HNS), which are regarded as morphological manifestations of augmented secretion of the anti-diuretic hormone (ADH) (see Gabe, 1966). Reserpine is reported to stimulate (Chaudhury, Chaudhury & Lu, 1962; Guzek & Leśnik, 1968), inhibit (Moses, 1964; Bridges & Thorn, 1970), or to have no effect (Boris & Stevenson, 1967) on ADH secretion. The amount of neurosecretory material (NSM) after reserpine treatment has been found to be unchanged (Eränkö, Hopsa, Kivalo & Telkkä, 1957) or diminished (e.g. Gabe, Tuchmann-Duplessis & Mercier-Parot, 1961). The present study reports the effect of reserpine on the histology of the HNS of the musk shrew after treatment with hypertonic saline.Animals were divided into six groups with 12 adults of either sex in each, and treated as follows: Group I: 3% NaCl solution (2 ml/day, i.p.) for 3–5

Journal

Journal of Endocrinology – Bioscientifica

Published: Aug 1, 1971

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