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INFLUENCE OF SUBSTANCE P ON HYPOTHALAMO-PITUITARY-ADRENOCORTICAL ACTIVITY IN THE RAT

INFLUENCE OF SUBSTANCE P ON HYPOTHALAMO-PITUITARY-ADRENOCORTICAL ACTIVITY IN THE RAT Sherrington School of Physiology and Biochemistry Department, St Thomas's Hospital Medical School, London, SEI and * Department of Pharmacology, Royal Free Hospital School of Medicine, London, WC1(Received 26 August 1977)Substance P is present in the hypothalamus in relatively high concentrations. Its release is K+-evoked and Ca2+-dependent (Iversen, Jessell & Kanazawa, 1976) and it may be a neurotransmitter substance in the hypothalamus. We have tested its effect on secretion of corticotrophin releasing factor (CRF) by the hypothalamus in vitro and on production of corticotrophin (ACTH) by the anterior pituitary gland of the rat both in vivo and in vitro.Production of CRF by rat hypothalami in vitro was stimulated by 5-hydroxytryptamine (5-HT) or acetylcholine (Gillham, Jones, Hillhouse & Burden, 1975; Buckingham & Hodges, 1977a) in the presence and absence of substance P. The activity of CRF was estimated by measuring cytochemically (Alghband-Zadeh, Daly, Bitensky & Chayen, 1974) the ACTH which http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

INFLUENCE OF SUBSTANCE P ON HYPOTHALAMO-PITUITARY-ADRENOCORTICAL ACTIVITY IN THE RAT

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Publisher
Bioscientifica
Copyright
Copyright © 1978 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0760183
Publisher site
See Article on Publisher Site

Abstract

Sherrington School of Physiology and Biochemistry Department, St Thomas's Hospital Medical School, London, SEI and * Department of Pharmacology, Royal Free Hospital School of Medicine, London, WC1(Received 26 August 1977)Substance P is present in the hypothalamus in relatively high concentrations. Its release is K+-evoked and Ca2+-dependent (Iversen, Jessell & Kanazawa, 1976) and it may be a neurotransmitter substance in the hypothalamus. We have tested its effect on secretion of corticotrophin releasing factor (CRF) by the hypothalamus in vitro and on production of corticotrophin (ACTH) by the anterior pituitary gland of the rat both in vivo and in vitro.Production of CRF by rat hypothalami in vitro was stimulated by 5-hydroxytryptamine (5-HT) or acetylcholine (Gillham, Jones, Hillhouse & Burden, 1975; Buckingham & Hodges, 1977a) in the presence and absence of substance P. The activity of CRF was estimated by measuring cytochemically (Alghband-Zadeh, Daly, Bitensky & Chayen, 1974) the ACTH which

Journal

Journal of Endocrinology – Bioscientifica

Published: Jan 1, 1978

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