Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/bioscientifica/hypothalamic-dopamine-and-catechol-oestrogens-in-rats-with-spontaneous-cY7rfoUgqq
References
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
- Publisher
- Bioscientifica
- Copyright
- Copyright © 1983 The Authors. All Rights Reserved.
- ISSN
- 0022-0795
- eISSN
- 1479-6805
- DOI
- 10.1677/joe.0.0960347
- Publisher site
- See Article on Publisher Site
Abstract
Dopamine concentration within the hypothalamus and its depletion after the administration of α-methyl-para-tyrosine were measured in young rats and compared with values obtained in aged animals with and without spontaneously occurring pituitary tumours. Old rats had significantly reduced hypothalamic dopamine concentrations and there was less depletion of dopamine compared with young animals but there were no differences between tumorous and non-tumorous animals. Hyperprolactinaemia induced in young animals caused a much greater depletion of hypothalamic dopamine than in old tumorous rats with comparable plasma prolactin concentrations. The catechol oestrogen 2-hydroxyoestradiol inhibited the release of prolactin from normal rat pituitary glands in vitro but measurement of catechol oestrogens in the hypothalamus showed no differences between young and old tumorous or non-tumorous rats. It is concluded that reduced dopamine concentration and an impaired response to hyperprolactinaemia in old rats may facilitate the growth of prolactin-secreting tumours arising in the pituitary gland.
Journal
Journal of Endocrinology – Bioscientifica
Published: Feb 1, 1983