Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

ENHANCEMENT OF GONADOTROPHIN ACTIVITY BY A RAT CEREBRAL TISSUE FRACTION

ENHANCEMENT OF GONADOTROPHIN ACTIVITY BY A RAT CEREBRAL TISSUE FRACTION SUMMARYThe gonadotrophin-enhancing effect of RCF-2 (prepared from aqueous extracts of rat cerebral tissue) was evaluated in several species of laboratory animals. RCF-2 alone did not induce any discernible gonadal response. Superovulation in immature rats treated with pregnant mare serum (PMS) or a combination of PMS and human chorionic gonadotrophin (HCG) was significantly increased by RCF-2. Ovulation in intact PMS-treated rats was increased to 84–127% above the response of controls. Hypophysectomized or intact rats treated with PMS + HCG shed 34–53% more ova when they were treated with 0·2 mg. RCF-2.An almost maximal uterine weight response was found in immature mice treated with RCF-2 in combination with subminimally effective doses of HCG. RCF-2 neither induced ovulation in post-partum rabbits nor in PMS-treated rats in which the release of luteinizing hormone was blocked. The results of these studies suggest that fraction RCF-2 does not act centrally to evoke a release of gonadotrophins but probably has a direct ovarian effect. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

ENHANCEMENT OF GONADOTROPHIN ACTIVITY BY A RAT CEREBRAL TISSUE FRACTION

HOPKINS, T. F.
Journal of Endocrinology , Volume 41 (3) – Jul 1, 1968
Download PDF
8 pages

Loading next page...
 
/lp/bioscientifica/enhancement-of-gonadotrophin-activity-by-a-rat-cerebral-tissue-X46xp9vT4x

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Bioscientifica
Copyright
Copyright © 1968 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0410345
Publisher site
See Article on Publisher Site

Abstract

SUMMARYThe gonadotrophin-enhancing effect of RCF-2 (prepared from aqueous extracts of rat cerebral tissue) was evaluated in several species of laboratory animals. RCF-2 alone did not induce any discernible gonadal response. Superovulation in immature rats treated with pregnant mare serum (PMS) or a combination of PMS and human chorionic gonadotrophin (HCG) was significantly increased by RCF-2. Ovulation in intact PMS-treated rats was increased to 84–127% above the response of controls. Hypophysectomized or intact rats treated with PMS + HCG shed 34–53% more ova when they were treated with 0·2 mg. RCF-2.An almost maximal uterine weight response was found in immature mice treated with RCF-2 in combination with subminimally effective doses of HCG. RCF-2 neither induced ovulation in post-partum rabbits nor in PMS-treated rats in which the release of luteinizing hormone was blocked. The results of these studies suggest that fraction RCF-2 does not act centrally to evoke a release of gonadotrophins but probably has a direct ovarian effect.

Journal

Journal of Endocrinology – Bioscientifica

Published: Jul 1, 1968

There are no references for this article.