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Effects of tactile and electrical stimuli upon release of vasoactive intestinal polypeptide in the mammalian penis

Effects of tactile and electrical stimuli upon release of vasoactive intestinal polypeptide in... ABSTRACTPlasma levels of vasoactive intestinal polypeptide (VIP) in the corpora cavernosa penis and dorsal penile veins greatly exceeded those measured in the limb or caudal veins during anaesthesia in various mammals (Bennett's wallaby, Barbary sheep, cheetah, puma, sooty mangabey, pigtail macaque and chimpanzee). Tactile stimulation of the penis immediately before or during collection of blood samples resulted in an increase. In the wallaby, VIP levels (mean ± s.e.m.) in blood samples collected from the flaccid penis in the absence of tactile stimulation were very low (0·6 ± 0·5 pmol/l). A 36-fold increase in VIP occurred after manual extension of the flaccid penis (24·8 ± 3·2 pmol/l) or during manually stimulated erections (25· 1 ± 1·7 pmol/l). Electrical stimulation of erection produced no significant increase in VIP levels (2·3±0·9 pmol/l) unless accompanied by tactile stimulation (17·5±1·4 pmol/l). These studies provide the first demonstration that sensory feedback from the penis plays an important role in regulating vasoactive intestinal polypeptidergic activity. Since VIP is a potent vasodilator its release due to tactile stimuli during copulation may play a role in the maintenance of penile erection.J. Endocr. (1984) 100, 249–252 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

Effects of tactile and electrical stimuli upon release of vasoactive intestinal polypeptide in the mammalian penis

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Publisher
Bioscientifica
Copyright
Copyright © 1984 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.1000249
Publisher site
See Article on Publisher Site

Abstract

ABSTRACTPlasma levels of vasoactive intestinal polypeptide (VIP) in the corpora cavernosa penis and dorsal penile veins greatly exceeded those measured in the limb or caudal veins during anaesthesia in various mammals (Bennett's wallaby, Barbary sheep, cheetah, puma, sooty mangabey, pigtail macaque and chimpanzee). Tactile stimulation of the penis immediately before or during collection of blood samples resulted in an increase. In the wallaby, VIP levels (mean ± s.e.m.) in blood samples collected from the flaccid penis in the absence of tactile stimulation were very low (0·6 ± 0·5 pmol/l). A 36-fold increase in VIP occurred after manual extension of the flaccid penis (24·8 ± 3·2 pmol/l) or during manually stimulated erections (25· 1 ± 1·7 pmol/l). Electrical stimulation of erection produced no significant increase in VIP levels (2·3±0·9 pmol/l) unless accompanied by tactile stimulation (17·5±1·4 pmol/l). These studies provide the first demonstration that sensory feedback from the penis plays an important role in regulating vasoactive intestinal polypeptidergic activity. Since VIP is a potent vasodilator its release due to tactile stimuli during copulation may play a role in the maintenance of penile erection.J. Endocr. (1984) 100, 249–252

Journal

Journal of Endocrinology – Bioscientifica

Published: Feb 1, 1984

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