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CONCENTRATION OF GONADOTROPHINS IN THE PLASMA AND TESTICULAR RESPONSIVENESS TO GONADOTROPHIC STIMULATION IN ANDROGEN-DEFICIENT C57BL/10J MICE

CONCENTRATION OF GONADOTROPHINS IN THE PLASMA AND TESTICULAR RESPONSIVENESS TO GONADOTROPHIC... Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545, U.S.A.(Received 24 May 1977)Deficient testicular function was suspected in male C57BL/10J mice from the observations that they have small testes (Shire & Bartke, 1972) and fail to produce the androgen-dependent pregnancy-blocking pheromone (Chapman & Whitten, 1969). Comparison with male DBA/2J mice and several other strains indicated that C57BL/10J mice have fewer spermatogonia, spermatocytes and spermatids, low testicular weight, a progressive decrease in the absolute weight of the testes after sexual maturation, excessive accumulation of esterified cholesterol in the testes and a low level of testosterone in the plasma (Bartke & Shire, 1972; Shire & Bartke, 1972; Bartke, 1974). The relative androgen deficiency of the C57BL/10J mice is also suggested by the observations of Ivanyi (1973), Hill, Clemens, Liu, Vessel & Johnson (1975) and Hoppe (1975).To define the causes of androgen deficiency in C57BL/10J mice, the levels of gonadotrophins in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

CONCENTRATION OF GONADOTROPHINS IN THE PLASMA AND TESTICULAR RESPONSIVENESS TO GONADOTROPHIC STIMULATION IN ANDROGEN-DEFICIENT C57BL/10J MICE

BARTKE, A.; ROBERSON, C.; DALTERIO, S.
Journal of Endocrinology , Volume 75 (3) – Dec 1, 1977
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Publisher
Bioscientifica
Copyright
Copyright © 1977 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0750441
Publisher site
See Article on Publisher Site

Abstract

Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545, U.S.A.(Received 24 May 1977)Deficient testicular function was suspected in male C57BL/10J mice from the observations that they have small testes (Shire & Bartke, 1972) and fail to produce the androgen-dependent pregnancy-blocking pheromone (Chapman & Whitten, 1969). Comparison with male DBA/2J mice and several other strains indicated that C57BL/10J mice have fewer spermatogonia, spermatocytes and spermatids, low testicular weight, a progressive decrease in the absolute weight of the testes after sexual maturation, excessive accumulation of esterified cholesterol in the testes and a low level of testosterone in the plasma (Bartke & Shire, 1972; Shire & Bartke, 1972; Bartke, 1974). The relative androgen deficiency of the C57BL/10J mice is also suggested by the observations of Ivanyi (1973), Hill, Clemens, Liu, Vessel & Johnson (1975) and Hoppe (1975).To define the causes of androgen deficiency in C57BL/10J mice, the levels of gonadotrophins in

Journal

Journal of Endocrinology – Bioscientifica

Published: Dec 1, 1977

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