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/lp/bioscientifica/blood-testis-barrier-evidence-for-intact-inter-sertoli-cell-junctions-m7TjN77Mpw
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- Publisher
- Bioscientifica
- Copyright
- Copyright © 1978 The Authors. All Rights Reserved.
- ISSN
- 0022-0795
- eISSN
- 1479-6805
- DOI
- 10.1677/joe.0.0760087
- Publisher site
- See Article on Publisher Site
Abstract
SUMMARYTo study the hormonal dependence of the blood–testis barrier, adult rats were hypophysectomized and the ultrastructural integrity of the inter-Sertoli cell junctional complex was examined at various times with a lanthanum tracer technique. It was found that the structural integrity of the inter-Sertoli cell junctions and their capacity to exclude lanthanum from the adluminal compartment were preserved up to 35 days after hypophysectomy. Furthermore, transport of newly formed spermatocytes through the inter-Sertoli cell junctions still occurred 20 days after hypophysectomy. It is therefore concluded that the function of the inter-Sertoli cell junctional complex is not directly dependent on gonadotrophic or androgenic hormones, but is regulated by other mechanisms.
Journal
Journal of Endocrinology – Bioscientifica
Published: Jan 1, 1978