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/lp/bioscientifica/anti-ovulatory-and-other-biological-properties-of-megestrol-acetate-17-YplsXdeJV0
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- Publisher
- Bioscientifica
- Copyright
- Copyright © 1963 The Authors. All Rights Reserved.
- ISSN
- 1470-1626
- eISSN
- 1741-7899
- DOI
- 10.1530/jrf.0.0050331
- Publisher site
- See Article on Publisher Site
Abstract
Summary.17αAcetoxy-6 methyl pregna 4:6-diene-3:20-dione (B.D.H. 1298), has been given the approved name of Megestrol acetate. It appears to be the most potent anti-ovulatory compound so far reported. It also possesses high oral progestational properties, being more active in the Clauberg assay than medroxy progesterone acetate, commercial norethynodrel and dimethisterone given orally, and progesterone subcutaneously. It is non-toxic in mice; prolonged administration to rats caused no adverse effects except at high doses in females where some adrenal atrophy was observed. It has no anabolic, androgenic or oestrogenic properties and no virilizing effect on the developing foetus.
Journal
Reproduction – Bioscientifica
Published: Jun 1, 1963