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A GENE CONTROLLING PLASMA SEROTONIN LEVELS IN MICE

A GENE CONTROLLING PLASMA SEROTONIN LEVELS IN MICE Serotonin levels in plasma have been found to differ significantly between inbred strains of mice. For example, the level in the C57BL/6By strain is more than twice that in BALB/cBy (Table 1). It was to determine the genetic basis of this difference that we have turned to a new genetic device, the recombinant inbred (RI) strains.RI strains are derived from the cross of two unrelated, but highly inbred progenitor strains, and then maintained independently, from the F2 generation onwards, under a regimen of strict inbreeding. The procedure genetically fixes the chance recombination of genes in generations following the F1 generation, although in ever decreasing amounts as full homozygosity is approached. The resulting battery of strains can be looked upon, in one sense, as a replicable recombinant population. The utility of such strains for analysing gene systems is described elsewhere (Bailey, 1971). Here we report the application of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

A GENE CONTROLLING PLASMA SEROTONIN LEVELS IN MICE

ELEFTHERIOU, B. E.; BAILEY, D. W.
Journal of Endocrinology , Volume 55 (1) – Oct 1, 1972
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Publisher
Bioscientifica
Copyright
Copyright © 1972 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0550225
Publisher site
See Article on Publisher Site

Abstract

Serotonin levels in plasma have been found to differ significantly between inbred strains of mice. For example, the level in the C57BL/6By strain is more than twice that in BALB/cBy (Table 1). It was to determine the genetic basis of this difference that we have turned to a new genetic device, the recombinant inbred (RI) strains.RI strains are derived from the cross of two unrelated, but highly inbred progenitor strains, and then maintained independently, from the F2 generation onwards, under a regimen of strict inbreeding. The procedure genetically fixes the chance recombination of genes in generations following the F1 generation, although in ever decreasing amounts as full homozygosity is approached. The resulting battery of strains can be looked upon, in one sense, as a replicable recombinant population. The utility of such strains for analysing gene systems is described elsewhere (Bailey, 1971). Here we report the application of

Journal

Journal of Endocrinology – Bioscientifica

Published: Oct 1, 1972

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