Role of gp130 in basal and exercise-trained skeletal muscle mitochondrial quality control

Role of gp130 in basal and exercise-trained skeletal muscle mitochondrial quality control Although the IL-6 family of cytokines has been implicated in the regulation of skeletal muscle protein turnover and metabolism, less is understood about its role in mitochondrial quality control. We examined the glycoprotein-130 receptor in the regulation of skeletal muscle mitochondria quality control in the basal and exercise-trained states. We report that the muscle glycoprotein-130 receptor modulates basal mitochondrial dynamics and autophagic processes and is not necessary for exercise-training mitochondrial adaptations to quality control. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Role of gp130 in basal and exercise-trained skeletal muscle mitochondrial quality control

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ISSN
8750-7587
eISSN
1522-1601
D.O.I.
10.1152/japplphysiol.01063.2017
Publisher site
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Abstract

Although the IL-6 family of cytokines has been implicated in the regulation of skeletal muscle protein turnover and metabolism, less is understood about its role in mitochondrial quality control. We examined the glycoprotein-130 receptor in the regulation of skeletal muscle mitochondria quality control in the basal and exercise-trained states. We report that the muscle glycoprotein-130 receptor modulates basal mitochondrial dynamics and autophagic processes and is not necessary for exercise-training mitochondrial adaptations to quality control.

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Jun 1, 2018

References

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