Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver

Primary cilia disruption differentially affects the infiltrating and resident macrophage... These studies are the first to address the contribution of the infiltrating and resident macrophage niche during progression of hepatorenal fibrocystic disease (HRFCD). We show that the number of infiltrating macrophages is significantly upregulated in HRFCD mouse models. Finally, we show that prevention of Ly6chi infiltrating macrophage accumulation significantly reduces biliary fibrosis, but not biliary hyperplasia, suggesting that this population may be responsible for the fibrotic progression of the disease in HRFCD patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver

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ISSN
0193-1857
eISSN
1522-1547
D.O.I.
10.1152/ajpgi.00381.2017
Publisher site
See Article on Publisher Site

Abstract

These studies are the first to address the contribution of the infiltrating and resident macrophage niche during progression of hepatorenal fibrocystic disease (HRFCD). We show that the number of infiltrating macrophages is significantly upregulated in HRFCD mouse models. Finally, we show that prevention of Ly6chi infiltrating macrophage accumulation significantly reduces biliary fibrosis, but not biliary hyperplasia, suggesting that this population may be responsible for the fibrotic progression of the disease in HRFCD patients.

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Jun 1, 2018

References

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