Mitochondrial basis for sex-differences in metabolism and exercise performance

Mitochondrial basis for sex-differences in metabolism and exercise performance Am J Physiol Regul Integr Comp Physiol 314: R848–R849, 2018; First published March 26, 2018; doi:10.1152/ajpregu.00077.2018. EDITORIAL FOCUS Mitochondrial basis for sex-differences in metabolism and exercise performance X Leonardo F. Ferreira Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida Submitted 21 March 2018; accepted in final form 21 March 2018 There are many physiological benefits of being a woman. This specific overexpression of CD36 resulted in three- to fourfold is most obvious in the simplest measures of “physiological higher fatty acid oxidation by contracting muscle (6). Thus, function”: survival rate and lifespan (1, 10, 15). Yet, longevity higher abundance of CD36, as shown by Miotto et al. (12) and benefits conferred by the female sex do not appear to translate others (9), may result in greater membrane translocation of the to whole body exercise performance. For example, women are protein upon contraction and heighten lipid metabolism during slower than men in endurance events with distances 42 km exercise. Consistent with this notion, women have higher lipid (or 26.2 miles), i.e., regular marathon. Metabolism is among oxidation during submaximal exercise (3, 16, 18). the physiological factors that contribute to survival and exer- The finding of lower ADP http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Mitochondrial basis for sex-differences in metabolism and exercise performance

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ISSN
0363-6119
eISSN
1522-1490
D.O.I.
10.1152/ajpregu.00077.2018
Publisher site
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Abstract

Am J Physiol Regul Integr Comp Physiol 314: R848–R849, 2018; First published March 26, 2018; doi:10.1152/ajpregu.00077.2018. EDITORIAL FOCUS Mitochondrial basis for sex-differences in metabolism and exercise performance X Leonardo F. Ferreira Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida Submitted 21 March 2018; accepted in final form 21 March 2018 There are many physiological benefits of being a woman. This specific overexpression of CD36 resulted in three- to fourfold is most obvious in the simplest measures of “physiological higher fatty acid oxidation by contracting muscle (6). Thus, function”: survival rate and lifespan (1, 10, 15). Yet, longevity higher abundance of CD36, as shown by Miotto et al. (12) and benefits conferred by the female sex do not appear to translate others (9), may result in greater membrane translocation of the to whole body exercise performance. For example, women are protein upon contraction and heighten lipid metabolism during slower than men in endurance events with distances 42 km exercise. Consistent with this notion, women have higher lipid (or 26.2 miles), i.e., regular marathon. Metabolism is among oxidation during submaximal exercise (3, 16, 18). the physiological factors that contribute to survival and exer- The finding of lower ADP

Journal

AJP - Regulatory, Integrative and Comparative PhysiologyThe American Physiological Society

Published: Jun 1, 2018

References

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