Am J Physiol Regul Integr Comp Physiol 314: R848–R849, 2018; First published March 26, 2018; doi:10.1152/ajpregu.00077.2018. EDITORIAL FOCUS Mitochondrial basis for sex-differences in metabolism and exercise performance X Leonardo F. Ferreira Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida Submitted 21 March 2018; accepted in ﬁnal form 21 March 2018 There are many physiological beneﬁts of being a woman. This speciﬁc overexpression of CD36 resulted in three- to fourfold is most obvious in the simplest measures of “physiological higher fatty acid oxidation by contracting muscle (6). Thus, function”: survival rate and lifespan (1, 10, 15). Yet, longevity higher abundance of CD36, as shown by Miotto et al. (12) and beneﬁts conferred by the female sex do not appear to translate others (9), may result in greater membrane translocation of the to whole body exercise performance. For example, women are protein upon contraction and heighten lipid metabolism during slower than men in endurance events with distances 42 km exercise. Consistent with this notion, women have higher lipid (or 26.2 miles), i.e., regular marathon. Metabolism is among oxidation during submaximal exercise (3, 16, 18). the physiological factors that contribute to survival and exer- The ﬁnding of lower ADP
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Jun 1, 2018
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