Mitigation of airways responsiveness by deep inflation of the lung

Mitigation of airways responsiveness by deep inflation of the lung The mechanisms by which deep inflation of the lung reverse bronchoconstriction and affect subsequent airway responsiveness have important potential implications for asthma, yet remain controversial. This study uses computational modeling to posit a mechanism by which sufficiently vigorous inflations applied during active bronchoconstriction not only transiently reverse bronchoconstriction, but also reduce subsequent airway responsiveness for a period of time. Fitting the model to published data in mice supports this notion. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Mitigation of airways responsiveness by deep inflation of the lung

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ISSN
8750-7587
eISSN
1522-1601
D.O.I.
10.1152/japplphysiol.00051.2018
Publisher site
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Abstract

The mechanisms by which deep inflation of the lung reverse bronchoconstriction and affect subsequent airway responsiveness have important potential implications for asthma, yet remain controversial. This study uses computational modeling to posit a mechanism by which sufficiently vigorous inflations applied during active bronchoconstriction not only transiently reverse bronchoconstriction, but also reduce subsequent airway responsiveness for a period of time. Fitting the model to published data in mice supports this notion.

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Jun 1, 2018

References

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