LOXury of Inhibiting Fibrosis in Volume Overload Cardiomyopathy Editorial Focus on Ms #H-00086-2018R2

LOXury of Inhibiting Fibrosis in Volume Overload Cardiomyopathy Editorial Focus on Ms... 3 LOXury of Inhibiting Fibrosis in Volume Overload 4 Cardiomyopathy 6 Sayantan Jana, PhD, Zamaneh Kassiri, PhD 7 Department of Physiology, Cardiovascular Research Center, University of Alberta, Edmonton, 8 AB 11 Correspondence to: 12 Zam Kassiri, MSc, PhD 13 Professor 14 Department of Physiology 15 Cardiovascular Research Centre 16 Mazankowski Alberta Heart Institute 17 University of Alberta 18 Edmonton, Alberta 19 Canada, T6G 2S2 21 Tel: (780) 492-9283 Fax: (780) 492-975 22 z.kassiri@ualberta.ca 25 A central characteristic of various cardiomyopathies is adverse structural remodeling of the 26 myocardium and the extracellular matrix (ECM). Hypertrophy is a common feature of 27 myocardial remodeling which is often associated with fibrosis (adverse ECM remodeling). In 28 broad terms, two major causes of myocardial hypertrophy are pressure overload (PO) and 29 volume overload (VO). PO is an increase in afterload which can occur secondary to hypertension 30 or aortic stenosis, and results in concentric hypertrophy (an increase in wall thickness without 31 chamber enlargement). VO occurs when the heart needs to handle a large volume of blood, for 32 instance secondary to aortic valve regurgitation or an excess rise in preload, which results in 33 eccentric hypertrophy (chamber enlargement without an increase in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

LOXury of Inhibiting Fibrosis in Volume Overload Cardiomyopathy Editorial Focus on Ms #H-00086-2018R2

AJP - Heart and Circulatory Physiology May 21, 2018

Loading next page...
 
/lp/aps/loxury-of-inhibiting-fibrosis-in-volume-overload-cardiomyopathy-RggkINZ1Rm
ISSN
0363-6135
eISSN
1522-1539
D.O.I.
10.1152/ajpheart.00315.2018
Publisher site
See Article on Publisher Site

Abstract

3 LOXury of Inhibiting Fibrosis in Volume Overload 4 Cardiomyopathy 6 Sayantan Jana, PhD, Zamaneh Kassiri, PhD 7 Department of Physiology, Cardiovascular Research Center, University of Alberta, Edmonton, 8 AB 11 Correspondence to: 12 Zam Kassiri, MSc, PhD 13 Professor 14 Department of Physiology 15 Cardiovascular Research Centre 16 Mazankowski Alberta Heart Institute 17 University of Alberta 18 Edmonton, Alberta 19 Canada, T6G 2S2 21 Tel: (780) 492-9283 Fax: (780) 492-975 22 z.kassiri@ualberta.ca 25 A central characteristic of various cardiomyopathies is adverse structural remodeling of the 26 myocardium and the extracellular matrix (ECM). Hypertrophy is a common feature of 27 myocardial remodeling which is often associated with fibrosis (adverse ECM remodeling). In 28 broad terms, two major causes of myocardial hypertrophy are pressure overload (PO) and 29 volume overload (VO). PO is an increase in afterload which can occur secondary to hypertension 30 or aortic stenosis, and results in concentric hypertrophy (an increase in wall thickness without 31 chamber enlargement). VO occurs when the heart needs to handle a large volume of blood, for 32 instance secondary to aortic valve regurgitation or an excess rise in preload, which results in 33 eccentric hypertrophy (chamber enlargement without an increase in

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: May 21, 2018

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off