3 LOXury of Inhibiting Fibrosis in Volume Overload 4 Cardiomyopathy 6 Sayantan Jana, PhD, Zamaneh Kassiri, PhD 7 Department of Physiology, Cardiovascular Research Center, University of Alberta, Edmonton, 8 AB 11 Correspondence to: 12 Zam Kassiri, MSc, PhD 13 Professor 14 Department of Physiology 15 Cardiovascular Research Centre 16 Mazankowski Alberta Heart Institute 17 University of Alberta 18 Edmonton, Alberta 19 Canada, T6G 2S2 21 Tel: (780) 492-9283 Fax: (780) 492-975 22 email@example.com 25 A central characteristic of various cardiomyopathies is adverse structural remodeling of the 26 myocardium and the extracellular matrix (ECM). Hypertrophy is a common feature of 27 myocardial remodeling which is often associated with fibrosis (adverse ECM remodeling). In 28 broad terms, two major causes of myocardial hypertrophy are pressure overload (PO) and 29 volume overload (VO). PO is an increase in afterload which can occur secondary to hypertension 30 or aortic stenosis, and results in concentric hypertrophy (an increase in wall thickness without 31 chamber enlargement). VO occurs when the heart needs to handle a large volume of blood, for 32 instance secondary to aortic valve regurgitation or an excess rise in preload, which results in 33 eccentric hypertrophy (chamber enlargement without an increase in
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: May 21, 2018
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