Resistance exercise impairs endothelial function, and this impairment is thought to be mediated by sustained elevation in blood pressure. Herein, we tested the hypothesis that resistance exercise-induced endothelial dysfunction would be prevented by high-intensity resistance exercise with low repetitions. This type of resistance exercise is known to induce temporal elevation in blood pressure due to low repetitions and long resting period between sets. Thirteen young healthy subjects completed three randomized experimental trials: (1) moderate-intensity with moderate repetitions trial (moderate-moderate trial); (2) low-intensity with high repetitions trial (low-high trial); (3) high-intensity with low repetitions trial (high-low trial). Following baseline brachial artery flow mediated dilation (FMD) and blood pressure measurements, subjects performed resistance exercise according to the different types of trial. Thereafter, brachial artery FMD and blood pressure measurements were repeated 10, 30, and 60 min after the exercise. Exercise-induced increases in blood flow and shear rate were significantly lower in the high-low trial than in the other two trials (P<0.05). Although systolic blood pressures were significantly elevated after exercise in all trials (P<0.05), the magnitudes of rise in blood pressure increase were significantly lower in the high-low trial than in the moderate-moderate and low-high trials (P<0.05). Moderate-moderate and low-high trials caused significant impairment in brachial artery FMD (P<0.05), which can be prevented through high-intensity resistance exercise with low repetitions (P>0.05). In conclusion, endothelial function was maintained by conducting high-intensity resistance exercise with low repetitions.
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: May 4, 2018
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