Effect of healthy ageing on cerebral blood flow, CO2 reactivity and neurovascular coupling during exercise

Effect of healthy ageing on cerebral blood flow, CO2 reactivity and neurovascular coupling during... We sought to make the first comparisons of duplex Doppler ultrasonography derived measures of cerebral blood flow during exercise in young and older individuals, and to assess whether healthy ageing influences the effect of exercise on neurovascular coupling (NVC) and cerebral vascular reactivity to changes in carbon dioxide (CVRCO2). In ten healthy young (23{plus minus}2yr; mean{plus minus}SD) and nine healthy older (66{plus minus}3yr) individuals, internal carotid artery (ICA) and vertebral artery (VA) blood flows were concurrently measured, along with middle and posterior cerebral artery mean blood velocity (MCAvmean and PCAvmean). Measures were made at rest and during leg cycling (75W and 35%Wmax). ICA and VA blood flow during dynamic exercise, undertaken at matched absolute (ICA: young 336{plus minus}95, older 352{plus minus}155; VA: young 95{plus minus}43, older 100{plus minus}30 ml•min-1) and relative (ICA: young 355{plus minus}125, older 323{plus minus}153; VA: young 115{plus minus}48, older 110{plus minus}32 ml•min-1) intensities, was not different between groups (p>0.670). The PCAvmean responses to visual stimulation (NVC) were blunted in older versus younger group at rest (16{plus minus}6 vs 23{plus minus}7%, p<0.026) and exercise; however, these responses were not changed from rest to exercise in either group. The ICA and VA CVRCO2 were comparable in both groups and unaltered during exercise. Collectively, our findings suggest that; 1) ICA and VA blood flow responses to dynamic exercise are similar in healthy young and older individuals, 2) NVC is blunted in healthy older individuals at rest and exercise, but is not different between rest to exercise in either group, 3) CVRCO2 is similar during exercise in healthy young and older groups. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Effect of healthy ageing on cerebral blood flow, CO2 reactivity and neurovascular coupling during exercise

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ISSN
8750-7587
eISSN
1522-1601
D.O.I.
10.1152/japplphysiol.00050.2018
Publisher site
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Abstract

We sought to make the first comparisons of duplex Doppler ultrasonography derived measures of cerebral blood flow during exercise in young and older individuals, and to assess whether healthy ageing influences the effect of exercise on neurovascular coupling (NVC) and cerebral vascular reactivity to changes in carbon dioxide (CVRCO2). In ten healthy young (23{plus minus}2yr; mean{plus minus}SD) and nine healthy older (66{plus minus}3yr) individuals, internal carotid artery (ICA) and vertebral artery (VA) blood flows were concurrently measured, along with middle and posterior cerebral artery mean blood velocity (MCAvmean and PCAvmean). Measures were made at rest and during leg cycling (75W and 35%Wmax). ICA and VA blood flow during dynamic exercise, undertaken at matched absolute (ICA: young 336{plus minus}95, older 352{plus minus}155; VA: young 95{plus minus}43, older 100{plus minus}30 ml•min-1) and relative (ICA: young 355{plus minus}125, older 323{plus minus}153; VA: young 115{plus minus}48, older 110{plus minus}32 ml•min-1) intensities, was not different between groups (p>0.670). The PCAvmean responses to visual stimulation (NVC) were blunted in older versus younger group at rest (16{plus minus}6 vs 23{plus minus}7%, p<0.026) and exercise; however, these responses were not changed from rest to exercise in either group. The ICA and VA CVRCO2 were comparable in both groups and unaltered during exercise. Collectively, our findings suggest that; 1) ICA and VA blood flow responses to dynamic exercise are similar in healthy young and older individuals, 2) NVC is blunted in healthy older individuals at rest and exercise, but is not different between rest to exercise in either group, 3) CVRCO2 is similar during exercise in healthy young and older groups.

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Jan 16, 2018

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