PHYSIOLOGY’S IMPACT PHYSIOLOGY 33: 250 –251, 2018. Aleksey V. Matveyenko Mayo Clinic, Rochester, Minnesota Published June 6, 2018; doi:10.1152/physiol.00012.2018 key physiological parameters in the labora- Consideration for Circadian Physiology in tory mouse exhibits distinct circadian peri- Rodent Research odicity (12). So what are some potential solutions for improved consideration for circadian physiology in preclinical animal research? The award of the Nobel Prize in Physiol- binding to conserved promoter regions Objective quantiﬁcation of circadian pe- ogy 2017 to Hall, Rosbash, and Young for along with concurrent recruitment of riodicity in a given physiological parame- their groundbreaking discoveries into cell-speciﬁc enhancers and repressors for ter requires collection of data spanning at mechanisms regulating circadian rhythms regulation of cell-speciﬁc target genes least two circadian cycles (i.e., at least has contributed to greater scientiﬁc appre- (14). Importantly, this complex regulatory 48 h). This degree of biological sampling ciation and recognition for the ﬁeld of cir- mechanism ensures the generation of ro- is obviously prohibitive for the majority of cadian physiology. The origins of circadian bust 24-h cycles of transcription and researchers; however, timing of physio- physiology certainly date back multiple de- translation with varying phases of expres- logical sampling should be consistent and
Physiology – The American Physiological Society
Published: Jul 1, 2018
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