PHYSIOLOGY’S IMPACT PHYSIOLOGY 33: 246 –249, 2018. Denis Noble University of Oxford, Oxford, United Kingdom Published June 6, 2018; doi:10.1152/physiol.00017.2018 nal and paternal effects (8). We have even identiﬁed some of Darwin’s imagined particles; they are the innumerable RNAs in sperm in the male line (23), and the many cytoplasmic materials in the inher- not yet been falsiﬁed. No one has yet Introduction ited egg cell in the maternal line, includ- shown that protein sequences can be ing the eukaryotic cell structure and translated into nucleic acid sequences.” The Central Dogma of molecular biology metabolism (25). Anonymous referee, 2017 has been widely misinterpreted to be a Weismann did not know any of this, of modern version of the Weismann Barrier. course. But he did have a brilliant simpli- This confuses cellular-level inheritance fying thought. This was that he could ex- with DNA inheritance and is therefore in- What is the Debate About? plain all the examples of the phenomenon correct. The consequences for biology given by Darwin in The Origin of Species generally and for physiology in particu- About 125 years ago, the hugely inﬂuen- even if one supposed that there were no lar are profound. Removing the confu-
Physiology – The American Physiological Society
Published: Jul 1, 2018
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