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Central Dogma or Central Debate?

Central Dogma or Central Debate? PHYSIOLOGY’S IMPACT PHYSIOLOGY 33: 246 –249, 2018. Denis Noble University of Oxford, Oxford, United Kingdom Published June 6, 2018; doi:10.1152/physiol.00017.2018 nal and paternal effects (8). We have even identified some of Darwin’s imagined particles; they are the innumerable RNAs in sperm in the male line (23), and the many cytoplasmic materials in the inher- not yet been falsified. No one has yet Introduction ited egg cell in the maternal line, includ- shown that protein sequences can be ing the eukaryotic cell structure and translated into nucleic acid sequences.” The Central Dogma of molecular biology metabolism (25). Anonymous referee, 2017 has been widely misinterpreted to be a Weismann did not know any of this, of modern version of the Weismann Barrier. course. But he did have a brilliant simpli- This confuses cellular-level inheritance fying thought. This was that he could ex- with DNA inheritance and is therefore in- What is the Debate About? plain all the examples of the phenomenon correct. The consequences for biology given by Darwin in The Origin of Species generally and for physiology in particu- About 125 years ago, the hugely influen- even if one supposed that there were no lar are profound. Removing the confu- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiology The American Physiological Society

Central Dogma or Central Debate?

Noble, Denis
Physiology , Volume 33 (4) – Jul 1, 2018
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ISSN
1548-9213
eISSN
1548-9221
DOI
10.1152/physiol.00017.2018
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Abstract

PHYSIOLOGY’S IMPACT PHYSIOLOGY 33: 246 –249, 2018. Denis Noble University of Oxford, Oxford, United Kingdom Published June 6, 2018; doi:10.1152/physiol.00017.2018 nal and paternal effects (8). We have even identified some of Darwin’s imagined particles; they are the innumerable RNAs in sperm in the male line (23), and the many cytoplasmic materials in the inher- not yet been falsified. No one has yet Introduction ited egg cell in the maternal line, includ- shown that protein sequences can be ing the eukaryotic cell structure and translated into nucleic acid sequences.” The Central Dogma of molecular biology metabolism (25). Anonymous referee, 2017 has been widely misinterpreted to be a Weismann did not know any of this, of modern version of the Weismann Barrier. course. But he did have a brilliant simpli- This confuses cellular-level inheritance fying thought. This was that he could ex- with DNA inheritance and is therefore in- What is the Debate About? plain all the examples of the phenomenon correct. The consequences for biology given by Darwin in The Origin of Species generally and for physiology in particu- About 125 years ago, the hugely influen- even if one supposed that there were no lar are profound. Removing the confu-

Journal

Physiology – The American Physiological Society

Published: Jul 1, 2018

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