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- Publisher
- Annual Reviews
- Copyright
- Copyright 2017 by Annual Reviews. All rights reserved
- ISSN
- 0147-006X
- eISSN
- 1545-4126
- DOI
- 10.1146/annurev-neuro-072116-031121
- pmid
- 28441116
- Publisher site
- See Article on Publisher Site
Abstract
Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy.
Journal
Annual Review of Neuroscience – Annual Reviews
Published: Jul 25, 2017