Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer

Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer It is speculated that genetic variants are associated with differential responses to nutrients (known as genediet interactions) and that these variations may be linked to different cancer risks. In this review, we critically evaluate the evidence across 314 meta-analyses of observational studies and randomized controlled trials of dietary risk factors and the five most common cancers (breast, lung, prostate, colorectal, and stomach). We also critically evaluate the evidence across 13 meta-analyses of observational studies of genediet interactions for the same cancers. Convincing evidence for association was found only for the intake of alcohol and whole grains in relation to colorectal cancer risk. Three nutrient associations had highly suggestive evidence and another 15 associations had suggestive evidence. Among the examined genediet interactions, only one had moderately strong evidence. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Nutrition Annual Reviews

Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer

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Publisher
Annual Reviews
Copyright
Copyright 2017 by Annual Reviews. All rights reserved
ISSN
0199-9885
eISSN
1545-4312
D.O.I.
10.1146/annurev-nutr-071715-051004
Publisher site
See Article on Publisher Site

Abstract

It is speculated that genetic variants are associated with differential responses to nutrients (known as genediet interactions) and that these variations may be linked to different cancer risks. In this review, we critically evaluate the evidence across 314 meta-analyses of observational studies and randomized controlled trials of dietary risk factors and the five most common cancers (breast, lung, prostate, colorectal, and stomach). We also critically evaluate the evidence across 13 meta-analyses of observational studies of genediet interactions for the same cancers. Convincing evidence for association was found only for the intake of alcohol and whole grains in relation to colorectal cancer risk. Three nutrient associations had highly suggestive evidence and another 15 associations had suggestive evidence. Among the examined genediet interactions, only one had moderately strong evidence.

Journal

Annual Review of NutritionAnnual Reviews

Published: Aug 21, 2017

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