Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/annual_reviews/inhibitory-plasticity-balance-control-and-codependence-2itVLj61Wc
- Publisher
- Annual Reviews
- Copyright
- Copyright 2017 by Annual Reviews. All rights reserved
- ISSN
- 0147-006X
- eISSN
- 1545-4126
- DOI
- 10.1146/annurev-neuro-072116-031005
- pmid
- 28598717
- Publisher site
- See Article on Publisher Site
Abstract
Inhibitory neurons, although relatively few in number, exert powerful control over brain circuits. They stabilize network activity in the face of strong feedback excitation and actively engage in computations. Recent studies reveal the importance of a precise balance of excitation and inhibition in neural circuits, which often requires exquisite fine-tuning of inhibitory connections. We review inhibitory synaptic plasticity and its roles in shaping both feedforward and feedback control. We discuss the necessity of complex, codependent plasticity mechanisms to build nontrivial, functioning networks, and we end by summarizing experimental evidence of such interactions.
Journal
Annual Review of Neuroscience – Annual Reviews
Published: Jul 25, 2017