Fleaing the Plague: Adaptations of Yersinia pestis to Its Insect Vector That Lead to Transmission

Fleaing the Plague: Adaptations of Yersinia pestis to Its Insect Vector That Lead to Transmission Interest in arthropod-borne pathogens focuses primarily on how they cause disease in humans. How they produce a transmissible infection in their arthropod host is just as critical to their life cycle, however. Yersinia pestis adopts a unique life stage in the digestive tract of its flea vector, characterized by rapid formation of a bacterial biofilm that is enveloped in a complex extracellular polymeric substance. Localization and adherence of the biofilm to the flea foregut is essential for transmission. Here, we review the molecular and genetic mechanisms of these processes and present a comparative evaluation and updated model of two related transmission mechanisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Fleaing the Plague: Adaptations of Yersinia pestis to Its Insect Vector That Lead to Transmission

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Publisher
Annual Reviews
ISSN
0066-4227
eISSN
1545-3251
D.O.I.
10.1146/annurev-micro-090816-093521
Publisher site
See Article on Publisher Site

Abstract

Interest in arthropod-borne pathogens focuses primarily on how they cause disease in humans. How they produce a transmissible infection in their arthropod host is just as critical to their life cycle, however. Yersinia pestis adopts a unique life stage in the digestive tract of its flea vector, characterized by rapid formation of a bacterial biofilm that is enveloped in a complex extracellular polymeric substance. Localization and adherence of the biofilm to the flea foregut is essential for transmission. Here, we review the molecular and genetic mechanisms of these processes and present a comparative evaluation and updated model of two related transmission mechanisms.

Journal

Annual Review of MicrobiologyAnnual Reviews

Published: Sep 8, 2017

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