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Vitamin E: Interactions with Free Radicals and Ascorbate

Vitamin E: Interactions with Free Radicals and Ascorbate The association of the tocopherols with lipid peroxidation in biological systems began in the early days of investigations on the chemical nature of these substances (25). Since then a great deal of work has attempted to relate the symptoms of vitamin E deficiency with peroxidative degradation of lipids, primarily those associated with membranous organelles. The signs of vitamin E deficiency in various species of animals are diverse, involving different tissues with different manifestations and different degrees of severity. Thus, it seems clear that the biological function of this vitamin is not specific in the sense of its being a cofactor for an enzymic reaction (as is the case for the B-complex vitamins). Given the appropriate species and certain dietary and environmental conditions, essentially any tissue can be made to develop characteristic signs as a result of a deficiency of this vitamin. In some human disease states, supple­ mentation of vitamin E at levels far exceeding those normally required amelio­ rates or improves the condition. Because of this multiplicity of effects, a common denominator that might explain the effects of a deficiency or excess of this vitamin is not obvious. A common denominator to consider, however, is 0199-9885/85/0715-0323$02.00 McCAY http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Nutrition Annual Reviews

Vitamin E: Interactions with Free Radicals and Ascorbate

McCay, P B
Annual Review of Nutrition , Volume 5 (1) – Jul 1, 1985
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References (25)

Publisher
Annual Reviews
Copyright
Copyright 1985 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0199-9885
eISSN
1545-4312
DOI
10.1146/annurev.nu.05.070185.001543
pmid
2992548
Publisher site
See Article on Publisher Site

Abstract

The association of the tocopherols with lipid peroxidation in biological systems began in the early days of investigations on the chemical nature of these substances (25). Since then a great deal of work has attempted to relate the symptoms of vitamin E deficiency with peroxidative degradation of lipids, primarily those associated with membranous organelles. The signs of vitamin E deficiency in various species of animals are diverse, involving different tissues with different manifestations and different degrees of severity. Thus, it seems clear that the biological function of this vitamin is not specific in the sense of its being a cofactor for an enzymic reaction (as is the case for the B-complex vitamins). Given the appropriate species and certain dietary and environmental conditions, essentially any tissue can be made to develop characteristic signs as a result of a deficiency of this vitamin. In some human disease states, supple­ mentation of vitamin E at levels far exceeding those normally required amelio­ rates or improves the condition. Because of this multiplicity of effects, a common denominator that might explain the effects of a deficiency or excess of this vitamin is not obvious. A common denominator to consider, however, is 0199-9885/85/0715-0323$02.00 McCAY

Journal

Annual Review of Nutrition – Annual Reviews

Published: Jul 1, 1985

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