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Genome rearrangements are frequent events in many organisms . Many of these events involve specific protein factors and specific DNA sequences . A segment of DNA that has the ability to translocate or reconfigure is generally called a mobile genetic element. While some rearrangements appear to take place by a mechanism unique to the particular reaction, many DNA elements appear to share a similar mechanism. The group of mobile genetic elements considered here may be classified as the transposon family. They are abundant and found within the genomes of a wide variety of organisms. Transposons are characterized by their ability to translocate to a variety of sites on the chromosome of the host organism. Transposons (in this review this term is used to represent all members of the family) can be divided into subgroups based on their transposition mechanism or the sequence similarities between their transposition proteins (1, 2). For example, the amino acid sequences of the integrases or IN proteins of retrotransposons and retroviruses are not only similar to each other, but also similar to that of the transposase of the IS3 family of prokaryotic insertion sequences (2a, 3, 4). Other subgroups of bacterial elements include the
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1992
Keywords: genome rearrangement; DNA transposition; retroviral DNA integration; Tn10; Tn7
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