Transglutaminases

Transglutaminases of cleavable cross-links, and solid phase reversible removal of specific proteins from biological systems. Space limitations necessitate mention of only the most recent findings, including significant unpublished results, with little background discussion and only brief critical appraisal. Varieties of Transglutaminases Transglutaminase activity is found to be widespread in cells and body fluids of a number of mammals (3-5). Table 1 presents a brief summary of selected distinguishing characteristics of those transglutaminases recognized to date in mammalian systems. The finding of the E-(y-glutamyl)lysine bond in an impressive array of other organisms implies a wide distribution of en­ zymes capable of catalyzing formation of this bond (11). Aside from the partial characterization of an enzyme of lobster muscle that catalyzes coagulation of the blood of these crustaceans (12) and one from Limulus lysate that is involved in stabilization of the soft clot in these crabs (13), enzymes from organisms other than mammals have not been studied. The nomenclature for the enzymes given in Table 1 will be used here. The shortcomings and imprecisions of the names used were discussed in detail earlier (1). Common usage, however, has ascribed meaning to the terms. Table 1 Properties, distribution, and functions of mammalian http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

Transglutaminases

Annual Review of Biochemistry, Volume 49 (1) – Jul 1, 1980

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Publisher
Annual Reviews
Copyright
Copyright 1980 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
D.O.I.
10.1146/annurev.bi.49.070180.002505
Publisher site
See Article on Publisher Site

Abstract

of cleavable cross-links, and solid phase reversible removal of specific proteins from biological systems. Space limitations necessitate mention of only the most recent findings, including significant unpublished results, with little background discussion and only brief critical appraisal. Varieties of Transglutaminases Transglutaminase activity is found to be widespread in cells and body fluids of a number of mammals (3-5). Table 1 presents a brief summary of selected distinguishing characteristics of those transglutaminases recognized to date in mammalian systems. The finding of the E-(y-glutamyl)lysine bond in an impressive array of other organisms implies a wide distribution of en­ zymes capable of catalyzing formation of this bond (11). Aside from the partial characterization of an enzyme of lobster muscle that catalyzes coagulation of the blood of these crustaceans (12) and one from Limulus lysate that is involved in stabilization of the soft clot in these crabs (13), enzymes from organisms other than mammals have not been studied. The nomenclature for the enzymes given in Table 1 will be used here. The shortcomings and imprecisions of the names used were discussed in detail earlier (1). Common usage, however, has ascribed meaning to the terms. Table 1 Properties, distribution, and functions of mammalian

Journal

Annual Review of BiochemistryAnnual Reviews

Published: Jul 1, 1980

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