Transcriptional Responses to Polypeptide Ligands: The JAK-STAT Pathway

Transcriptional Responses to Polypeptide Ligands: The JAK-STAT Pathway Cytokines and growth factors regulate multiple aspects of cell growth through their interactions with specific receptors. These receptors initiate signals di­ rected at both the cytoplasmic and the nuclear compartments. Many of the nuclear signals culminate in the induction of new genes. Characterization of the ability of IFN-a. to rapidly induce new genes has led to the identification of a new signaling paradigm, the JAK-STAT (Signal Transducers and Activa­ tors of Transcription) pathway. In the IFN-a. pathway, two receptor associated tyrosine kinases from the JAK family, Jald and Tyk2, mediate the activation of two latent cytoplasmic transcription factors, Statl and Stat2. More recent studies have not only determined that this pathway is used extensively, but have led to the identification of additional components (e.g., Jak2, Jak3, Stat3, Stat4, Stat5, and Stat6). This review will examine how these components mediate the transduction of signal directly from receptor to nucleus. INTRODUCTION Initially uncovered by experiments aimed at understanding IFN-a. and IFN-y­ induced transcriptional activation, a new pathway of signal transduction from the cell surface to genes in the nucleus has been recently recognized (1). The pathway is called the JAK-STAT pathway: First, one or more members of the JAK family http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

Transcriptional Responses to Polypeptide Ligands: The JAK-STAT Pathway

Annual Review of Biochemistry, Volume 64 (1) – Jul 1, 1995

Loading next page...
 
/lp/annual-reviews/transcriptional-responses-to-polypeptide-ligands-the-jak-stat-pathway-uohy10oPFV
Publisher
Annual Reviews
Copyright
Copyright 1995 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
D.O.I.
10.1146/annurev.bi.64.070195.003201
Publisher site
See Article on Publisher Site

Abstract

Cytokines and growth factors regulate multiple aspects of cell growth through their interactions with specific receptors. These receptors initiate signals di­ rected at both the cytoplasmic and the nuclear compartments. Many of the nuclear signals culminate in the induction of new genes. Characterization of the ability of IFN-a. to rapidly induce new genes has led to the identification of a new signaling paradigm, the JAK-STAT (Signal Transducers and Activa­ tors of Transcription) pathway. In the IFN-a. pathway, two receptor associated tyrosine kinases from the JAK family, Jald and Tyk2, mediate the activation of two latent cytoplasmic transcription factors, Statl and Stat2. More recent studies have not only determined that this pathway is used extensively, but have led to the identification of additional components (e.g., Jak2, Jak3, Stat3, Stat4, Stat5, and Stat6). This review will examine how these components mediate the transduction of signal directly from receptor to nucleus. INTRODUCTION Initially uncovered by experiments aimed at understanding IFN-a. and IFN-y­ induced transcriptional activation, a new pathway of signal transduction from the cell surface to genes in the nucleus has been recently recognized (1). The pathway is called the JAK-STAT pathway: First, one or more members of the JAK family

Journal

Annual Review of BiochemistryAnnual Reviews

Published: Jul 1, 1995

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off