651 0066-4154/87/0701-0651$02.00 GANEM & V ARMUS PERSPECTIVE Although the recognition of hepatitis as an infectious disease dates to antiqÂ uity, the identification of hepatitis B virus (HBV) as one of its important causes was not achieved until the late 1 960s . Over the ensuing 10 years, rapid progress was made in the structural and biological characterization of the virus, but its narrow host range and inability to be propagated in cultured cells stymied early efforts to elucidate the molecular details of viral replication. Within the past decade, however, the development of workable animal modÂ els of HBV infection, together with ongoing advances in molecular genetics, has brought these once-refractory areas into full experimental view . The result has been the revelation of a remarkably intricate life cycle, at each step of which unusual strategies are employed. The replication of viral DNA proÂ ceeds via reverse transcription of an RNA intermediate, using protein and RNA primers for the generation of the first and second DNA strands. Large fractions of the genome are translated in more than one reading frame; within a frame, proteins from multiple in-phase initiator codons are expressed from overlapping transcripts. The resulting closely related gene
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1987
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera