The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of... Cell adhesion molecules are thought to play an important role in guiding cell migration and localization in the development of the embryo and in organogenesis. In the immune system, cell adhesion molecules enhance the efficiency of specific receptor-dependent lymphocyte-accessory cell and lymphocyte-target cell interactions; they are also important in leukocyte­ endothelial cell i nteractions and lymphocyte recirculation. Recent studies with monoclonal antibodies (MAb) that perturb antigen-receptor-depen­ dent T-Iymphocyte functions have defined a number of cell surface mol­ ecules that are associated with lymphocyte function (lymphocyte function­ associated or LFA antigens) (Table I). The antigens LFA-I, CD2, LFA3, CD8, and CD4 appear to enhance antigen-specific functions by acting as cell adhesion molecules. Further studies have shown that the LFA- l , CD2, and L FA-3 molecules are also important in antigen-independent T-lymphocyte adherence and function and that the LFA- I molecule i s important in the adherence and function o f essentially all leukocyte cell types. This review focuses on LFA- I, CD2, and LFA-3. Thc role of CD4 and CD8 is reviewed by Littman in this volume. We discuss (a) the con­ tributions of LFA- l , CD2, and LFA-3 to antigen-dependent and antigen223 0732-0582/87/041 0-0223$02.00 IV IV http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

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Publisher
Annual Reviews
Copyright
Copyright 1987 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.05.040187.001255
pmid
3109455
Publisher site
See Article on Publisher Site

Abstract

Cell adhesion molecules are thought to play an important role in guiding cell migration and localization in the development of the embryo and in organogenesis. In the immune system, cell adhesion molecules enhance the efficiency of specific receptor-dependent lymphocyte-accessory cell and lymphocyte-target cell interactions; they are also important in leukocyte­ endothelial cell i nteractions and lymphocyte recirculation. Recent studies with monoclonal antibodies (MAb) that perturb antigen-receptor-depen­ dent T-Iymphocyte functions have defined a number of cell surface mol­ ecules that are associated with lymphocyte function (lymphocyte function­ associated or LFA antigens) (Table I). The antigens LFA-I, CD2, LFA3, CD8, and CD4 appear to enhance antigen-specific functions by acting as cell adhesion molecules. Further studies have shown that the LFA- l , CD2, and L FA-3 molecules are also important in antigen-independent T-lymphocyte adherence and function and that the LFA- I molecule i s important in the adherence and function o f essentially all leukocyte cell types. This review focuses on LFA- I, CD2, and LFA-3. Thc role of CD4 and CD8 is reviewed by Littman in this volume. We discuss (a) the con­ tributions of LFA- l , CD2, and LFA-3 to antigen-dependent and antigen223 0732-0582/87/041 0-0223$02.00 IV IV

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 1, 1987

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