Cell adhesion molecules are thought to play an important role in guiding cell migration and localization in the development of the embryo and in organogenesis. In the immune system, cell adhesion molecules enhance the efficiency of specific receptor-dependent lymphocyte-accessory cell and lymphocyte-target cell interactions; they are also important in leukocyteÂ endothelial cell i nteractions and lymphocyte recirculation. Recent studies with monoclonal antibodies (MAb) that perturb antigen-receptor-depenÂ dent T-Iymphocyte functions have defined a number of cell surface molÂ ecules that are associated with lymphocyte function (lymphocyte functionÂ associated or LFA antigens) (Table I). The antigens LFA-I, CD2, LFA3, CD8, and CD4 appear to enhance antigen-specific functions by acting as cell adhesion molecules. Further studies have shown that the LFA- l , CD2, and L FA-3 molecules are also important in antigen-independent T-lymphocyte adherence and function and that the LFA- I molecule i s important in the adherence and function o f essentially all leukocyte cell types. This review focuses on LFA- I, CD2, and LFA-3. Thc role of CD4 and CD8 is reviewed by Littman in this volume. We discuss (a) the conÂ tributions of LFA- l , CD2, and LFA-3 to antigen-dependent and antigen223 0732-0582/87/041 0-0223$02.00 IV IV
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1987
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