Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
PERSPECTIVES AND SUMMARY When cultured cells or whole organisms are exposed to elevated temperatures, they respond by synthesizing a small number of highly conserved proteins, the heat-shock proteins, or hsps. This response is universal. It has been observed in every organism in which it has been sought, from eubacteria to archebacteria, from mice to soybeans. It is found in nearly every cell- and tissue-type of multicellular organ isms, in explanted tissues, and in cultured cells. It may be 0066-4154/86/0701-1151$02.00 LINDQUIST that some creature living in the depths of the ocean does not have a heat-shock response, but that is doubtful. The proteins are induced by a wide variety of other stresses, seem to have very general protective functions, and may well play a role in nonnal growth and development. Man has long studied the effects of heat on himself and other living things, but studies of the heat-shock response per se began in 1962 with the publication of a little-noticed paper describing a new set of puffs on the salivary gland chromosomes of a fruit fly,Drosophila busckii, puffs induced by heat, di nitrophenol, or sodium salicylate (1). For the next decade the response was studied solely at the
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1986
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.