Peter B. Sargent Departments of Stomatology and Physiology and the Neuroscience Graduate Program, University of California, San Francisco, California 941 43-05 1 2 KEY WORDS: calcium, presynaptic, heterologous expression, transsynaptic reguÂ lation, channel gating The transmitter acetylcholine (ACh) acts on two different classes of recepÂ tors: nicotinic and muscarinic. Nicotinic receptors (nAChRs) are directly gated or ionotropic receptors and are members of a supergene family that also includes glycine, GABAA, and 5-HT 3 receptors. Muscarinic receptors are metabotropic receptors and belong to a different supergene family. In this review, I concentrate on nAChRs expressed by neurons, which are distinct from skeletal muscle nAChRs. Several recent reviews have treated both neuronal and muscle nAChRs (Claudio 1 989; Galzi et a1 1 99 1 ; Lukas & Bencherif 1 992; Schmidt 1 988; Schuetze & Role 1 987), whereas others have focused on neuronal nAChRs (Deneris et al 1 99 1 ; Lindstrom et al 1 987; Luetje et a1 1 990a; Role 1 992). Over the past several years, the application of molecular, immunological, and physiological techniques has greatly expanded our knowledge of neuronal nAChRs. By applying tools and insight gained from the study of muscle nAChRs, neuronal nAChRs
Annual Review of Neuroscience – Annual Reviews
Published: Mar 1, 1993
Keywords: calcium; presynaptic; heterologous expression; transsynaptic regulation; channel gating
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