The past 25 years has seen our appreciation of the function of dopamine (DA) in the brain elevated from that of a precursor for norepinephrine to a neurotransmitter in its own right. The association of disturbances of dopaminergic neurotransmission with neurological and psychiatric disorÂ ders has further emphasized the crucial role of this neurotransmitter in normal brain function.Dopaminergic agonists have a firmly established role in the treatment of Parkinson's disease and may be of value in the therapy of tardive dyskinesia.Dopaminergic antagonists have a longer history in the treatment of schizophrenia, Huntington's disease, and Gilles de la TouretÂ te's syndrome. Since 1975, the elegantly simple radioligand binding technique has alÂ lowed direct examination of the interactions of agonists and antagonists with putative dopamine receptors (DARs), and these studies form the major focus of this review. Such studies have complemented investigations ofDA regulation of adenylate cyclase activity and hormone release in various tissues. Although problems remain, the correspondence between such radiÂ oligand binding sites and functional DARs is steadily being established. These experiments have clearly dividedDARs into distinct subtypes, much as was done earlier for the alpha and beta adrenergic receptors. These findings will have a profound effect on
Annual Review of Neuroscience – Annual Reviews
Published: Mar 1, 1983
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