Few enzymes have commanded as much attention or are the subject of as much study as cytochrome c oxidase (EC 220.127.116.11). A book has been dedicated 569 0066-4154/90/0701-0569$02.00 CAPALDI entirely to the structure and functioning of the enzyme (1), and meetings have been organized to discuss this protein alone (2). Cytochrome c oxidase is a complex metalloprotein that provides a critical function in cellular respiration in both prokaryotes and eukaryotes. The enzyme catalyzes the reaction 4H+ + 4e- + O2;;= 2 H20. Energy released in this exogonic reaction is conserved as a pH gradient and membrane potential across the membrane barrier, generated in part by H+ consumption and also by proton translocation through the protein complex. This review focuses on aartype cytochrome c oxidase, as opposed to ab- or ao-type oxidases, which are found in some bacteria (3) , and considers the structure-function relaÂ tionships that are emerging from studies on the enzyme from a variety of organisms, including bacteria such as Paracoccus denitrificans, and euÂ karyotes as various as slime mold, yeast, and human. Characterization of cytochrome c oxidase from yeast has opened the way for studying the biogenesis of the enzyme. Cytochrome c oxidase in euÂ
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1990
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera