AND PERSPECTIVES Biosynthesis of glycoproteins, as well as the structure of their glycoconjuÂ gates, has been the focus of investigation on complex carbohydrates for the 'Abbreviations used: CSG, cell-surface glycoprotein; PAS, periodic acid-Schiff; SDS-PAGE, sodium dodel:yl sulfate-polyacrylamide gel electrophoresis; GlcNAc, N-acetylglucosamine, GalÂ NAc, N-acetylgalactosamine. 2Dedicated to Dr. R . Purrmann on the occasion of his 75th birthday. 0000-4154/89/0701-0173$02.00 LECHNER & WIELAND last decade. Most of our knowledge on this subject has been obtained by research on eukaryotic organisms, primarily on cultures of mammalian cells and on yeast. These studies have led to a detailed insight into the chemistry underlying protein-glycosylation, including the elucidation (1) of the coordiÂ ' nate action of various cell organelles during generation of the N-glycosyl bond, both in the construction of a variety of protein-linked carbohydrate structures, as well as in the transport of newly synthesized proteins. These results have overshadowed the observation that glycoproteins are also comÂ ponents of prokaryotic organisms, although reports on bacterial glycoproteins have existed for a few years (2-6). Prokaryotes do of course possess an extreme variety of carbohydrates as constituents of their cell surfaces, but these carbohydrates are either attached to lipids or are part of elongated glycan
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1989
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