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Signaling and Immune Regulation in Melanoma Development and Responses to Therapy

Signaling and Immune Regulation in Melanoma Development and Responses to Therapy Melanoma is a complex and genomically diverse malignancy, and new genes and signaling pathways involved in pathogenesis continue to be discovered. Mechanistic insights into gene and immune regulation in melanoma have led to the development of numerous successful and innovative pharmacologic agents over recent years. Multiple targeted therapies and immunotherapies have already entered the clinic, becoming new standards of care and transforming the prognosis for many patients with malignant melanoma. In this review, we provide an overview of the current understanding of signaling and immune regulation in melanoma and implications for responses to treatment, organized in the framework of hallmark characteristics in cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pathology: Mechanisms of Disease Annual Reviews

Signaling and Immune Regulation in Melanoma Development and Responses to Therapy

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Publisher
Annual Reviews
Copyright
Copyright © 2017 by Annual Reviews. All rights reserved
ISSN
1553-4006
eISSN
1553-4014
DOI
10.1146/annurev-pathol-052016-100208
pmid
27959628
Publisher site
See Article on Publisher Site

Abstract

Melanoma is a complex and genomically diverse malignancy, and new genes and signaling pathways involved in pathogenesis continue to be discovered. Mechanistic insights into gene and immune regulation in melanoma have led to the development of numerous successful and innovative pharmacologic agents over recent years. Multiple targeted therapies and immunotherapies have already entered the clinic, becoming new standards of care and transforming the prognosis for many patients with malignant melanoma. In this review, we provide an overview of the current understanding of signaling and immune regulation in melanoma and implications for responses to treatment, organized in the framework of hallmark characteristics in cancer.

Journal

Annual Review of Pathology: Mechanisms of DiseaseAnnual Reviews

Published: Jan 24, 2017

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