ROLE OF BLOOD FLOW IN THE REGULATION OF MUSCLE GLUCOSE UPTAKE

ROLE OF BLOOD FLOW IN THE REGULATION OF MUSCLE GLUCOSE UPTAKE ▪ Abstract Insulin vasodilates skeletal muscle vasculature via an endothelium-derived nitric oxide–dependent mechanism. Data suggests that insulin interacts directly with the endothelium to cause nitric oxide release. This insulin-mediated increase in muscle perfusion accounts for ∼30% of insulin's overall action to stimulate muscle glucose uptake, suggesting a role for insulin and glucose delivery as a determinant of insulin action. Hindlimb perfusion experiments, where perfusion rate is fixed, suggest that changes in distribution of microcirculatory perfusion can modulate substrate uptake. The potential role of insulin to enhance flow through capillary networks that are efficient at nutrient transfer to tissue (nutritive flow) relative to non-nutritive flow is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Nutrition Annual Reviews

ROLE OF BLOOD FLOW IN THE REGULATION OF MUSCLE GLUCOSE UPTAKE

Annual Review of Nutrition, Volume 17 (1) – Jul 1, 1997

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Publisher
Annual Reviews
Copyright
Copyright © 1997 by Annual Reviews Inc. All rights reserved
Subject
Review Articles
ISSN
0199-9885
eISSN
1545-4312
DOI
10.1146/annurev.nutr.17.1.487
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Insulin vasodilates skeletal muscle vasculature via an endothelium-derived nitric oxide–dependent mechanism. Data suggests that insulin interacts directly with the endothelium to cause nitric oxide release. This insulin-mediated increase in muscle perfusion accounts for ∼30% of insulin's overall action to stimulate muscle glucose uptake, suggesting a role for insulin and glucose delivery as a determinant of insulin action. Hindlimb perfusion experiments, where perfusion rate is fixed, suggest that changes in distribution of microcirculatory perfusion can modulate substrate uptake. The potential role of insulin to enhance flow through capillary networks that are efficient at nutrient transfer to tissue (nutritive flow) relative to non-nutritive flow is discussed.

Journal

Annual Review of NutritionAnnual Reviews

Published: Jul 1, 1997

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