Regulation of Ion Channel Distribution at Synapses

Regulation of Ion Channel Distribution at Synapses Synapses are regions of highly specialized contact between two cells. The clustered distribution of both ligand·gated and voltage· activated ion chan· nels is one of the best known examples of molecular specialization in synaptic membranes. At the neuromuscular junction, ion channel clus­ tering is responsible for rapid signal transmission and ensures that the postsynaptic response initiates a propagated action potential. At some excitatory synapses between neurons, potentiation of synaptic strength depends, in part, on coclustering of transmitter receptors. Thus, regulation of the ion channel distribution is not only important in signal transmission, but possibly also in synaptic plasticity. The mechanisms by which ion channels are anchored at synaptic sites, and the way in which this process is regulated by the nerve, are best understood at the neuromuscular junction. This review focuses on the neuromuscular junction, with discussions of both pre· and postsynaptic elements. Studies of the mechanisms of clustering in the central nervous system (CNS) are less well advanced. Therefore, three of the best charac­ terized examples are considered. Although ion channels are clustered in other parts of the neuron (e.g. nodes of Ranvier, axon hillock), this review is restricted to ion channel distribution at the synapse. THE http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Neuroscience Annual Reviews

Regulation of Ion Channel Distribution at Synapses

Annual Review of Neuroscience, Volume 16 (1) – Mar 1, 1993

Loading next page...
 
/lp/annual-reviews/regulation-of-ion-channel-distribution-at-synapses-Ka2atWz5j2
Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0147-006X
eISSN
1545-4126
DOI
10.1146/annurev.ne.16.030193.002023
Publisher site
See Article on Publisher Site

Abstract

Synapses are regions of highly specialized contact between two cells. The clustered distribution of both ligand·gated and voltage· activated ion chan· nels is one of the best known examples of molecular specialization in synaptic membranes. At the neuromuscular junction, ion channel clus­ tering is responsible for rapid signal transmission and ensures that the postsynaptic response initiates a propagated action potential. At some excitatory synapses between neurons, potentiation of synaptic strength depends, in part, on coclustering of transmitter receptors. Thus, regulation of the ion channel distribution is not only important in signal transmission, but possibly also in synaptic plasticity. The mechanisms by which ion channels are anchored at synaptic sites, and the way in which this process is regulated by the nerve, are best understood at the neuromuscular junction. This review focuses on the neuromuscular junction, with discussions of both pre· and postsynaptic elements. Studies of the mechanisms of clustering in the central nervous system (CNS) are less well advanced. Therefore, three of the best charac­ terized examples are considered. Although ion channels are clustered in other parts of the neuron (e.g. nodes of Ranvier, axon hillock), this review is restricted to ion channel distribution at the synapse. THE

Journal

Annual Review of NeuroscienceAnnual Reviews

Published: Mar 1, 1993

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off