REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE

REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE ▪ Abstract Recent embryological studies are beginning to establish that the underlying organization of the forebrain may be reduced to relatively simple elements that are common to all vertebrates. We begin this chapter by reviewing studies that describe the similarities in prospective fate and molecular organization of the developing neural plate in fish, frogs, chickens, and mice. The chapter next addresses mechanisms that regulate regional specification in the anterior central nervous system. There is now evidence that the axial mesendoderm anterior to the notochord (the prechordal plate) has a central role in induction of the floor and basal plate primordia (hypothalamus) of the forebrain. Patterning of the anterolateral neural plate (telencephalon) may be regulated by FGF8 produced in the anterior neural ridge. Thus, the synthesis of information from fate mapping and experimental embryological and genetic studies is illuminating the mechanisms that generate the different components of the forebrain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Neuroscience Annual Reviews

REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE

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Publisher
Annual Reviews
Copyright
Copyright © 1998 by Annual Reviews Inc. All rights reserved
Subject
Review Articles
ISSN
0147-006X
eISSN
1545-4126
DOI
10.1146/annurev.neuro.21.1.445
pmid
9530503
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Recent embryological studies are beginning to establish that the underlying organization of the forebrain may be reduced to relatively simple elements that are common to all vertebrates. We begin this chapter by reviewing studies that describe the similarities in prospective fate and molecular organization of the developing neural plate in fish, frogs, chickens, and mice. The chapter next addresses mechanisms that regulate regional specification in the anterior central nervous system. There is now evidence that the axial mesendoderm anterior to the notochord (the prechordal plate) has a central role in induction of the floor and basal plate primordia (hypothalamus) of the forebrain. Patterning of the anterolateral neural plate (telencephalon) may be regulated by FGF8 produced in the anterior neural ridge. Thus, the synthesis of information from fate mapping and experimental embryological and genetic studies is illuminating the mechanisms that generate the different components of the forebrain.

Journal

Annual Review of NeuroscienceAnnual Reviews

Published: Mar 1, 1998

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