RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion

RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion ▪ Abstract Synaptic vesicle exocytosis occurs in consecutive steps: docking, which specifically attaches vesicles to the active zone; priming, which makes the vesicles competent for Ca 2+ -triggered release and may involve a partial fusion reaction; and the final Ca 2+ -regulated step that completes fusion. Recent evidence suggests that the critical regulation of the last step in the reaction is mediated by two proteins with opposite actions: synaptotagmin, a Ca 2+ -binding protein that is essential for Ca 2+ -triggered release and probably serves as the Ca 2+ -sensor in fusion, and rab3, which limits the number of vesicles that can be fused as a function of Ca 2+ in order to allow a temporally limited, repeatable signal. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Neuroscience Annual Reviews

RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion

Annual Review of Neuroscience, Volume 21 (1) – Mar 1, 1998

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Publisher
Annual Reviews
Copyright
Copyright © 1998 by Annual Reviews Inc. All rights reserved
Subject
Review Articles
ISSN
0147-006X
eISSN
1545-4126
DOI
10.1146/annurev.neuro.21.1.75
pmid
9530492
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Synaptic vesicle exocytosis occurs in consecutive steps: docking, which specifically attaches vesicles to the active zone; priming, which makes the vesicles competent for Ca 2+ -triggered release and may involve a partial fusion reaction; and the final Ca 2+ -regulated step that completes fusion. Recent evidence suggests that the critical regulation of the last step in the reaction is mediated by two proteins with opposite actions: synaptotagmin, a Ca 2+ -binding protein that is essential for Ca 2+ -triggered release and probably serves as the Ca 2+ -sensor in fusion, and rab3, which limits the number of vesicles that can be fused as a function of Ca 2+ in order to allow a temporally limited, repeatable signal.

Journal

Annual Review of NeuroscienceAnnual Reviews

Published: Mar 1, 1998

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