Protein Glycosylation in Yeast

Protein Glycosylation in Yeast PERSPECTIVES AND SUMMARY Chimeras often found themselves in important posItions. Centaurs (man/ horse) were magical shape-shifters who taught the Hellenic gods . Mermaids (woman/fish) were regarded so highly that, up to the 1 9th century, English law claimed "all mermaids found in British waters" for the Crown . Surely no less important roles are acknowledged in modem times for glycoproteins 0066-4154/87/0701-0915$02.00 KUKURUZINSKA, BERGH, & JACKSON (sugar/protein). The diverse processes in which they are involved include: cell-cell recognition, hormone-receptor binding, interactions between micro­ organisms and their hosts, protein targeting, malignant transformation, and phagocytosis. The role of carbohydrate in these phenomena has been the subject of elaborate investigations, primarily conducted using mammalian and avian systems (1,2). The inherent complexity of these systems, however, has limited experimental approach. Within the last decade, investigators have begun to recognize an alternative in the yeast systems, which offer straightfor­ ward genetics, standard biochemical approaches, and ease of manipulation. It is feasible to isolate mutants, to clone genes, and to disrupt them to determine their essentiality. Increasingly, yeasts have been used as hosts for the expres­ sion of heterologous genes, because yeasts and higher eukaryotes share many metabolic pathways. One of these is the asparagine-linked http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

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Publisher
Annual Reviews
Copyright
Copyright 1987 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
DOI
10.1146/annurev.bi.56.070187.004411
pmid
3304149
Publisher site
See Article on Publisher Site

Abstract

PERSPECTIVES AND SUMMARY Chimeras often found themselves in important posItions. Centaurs (man/ horse) were magical shape-shifters who taught the Hellenic gods . Mermaids (woman/fish) were regarded so highly that, up to the 1 9th century, English law claimed "all mermaids found in British waters" for the Crown . Surely no less important roles are acknowledged in modem times for glycoproteins 0066-4154/87/0701-0915$02.00 KUKURUZINSKA, BERGH, & JACKSON (sugar/protein). The diverse processes in which they are involved include: cell-cell recognition, hormone-receptor binding, interactions between micro­ organisms and their hosts, protein targeting, malignant transformation, and phagocytosis. The role of carbohydrate in these phenomena has been the subject of elaborate investigations, primarily conducted using mammalian and avian systems (1,2). The inherent complexity of these systems, however, has limited experimental approach. Within the last decade, investigators have begun to recognize an alternative in the yeast systems, which offer straightfor­ ward genetics, standard biochemical approaches, and ease of manipulation. It is feasible to isolate mutants, to clone genes, and to disrupt them to determine their essentiality. Increasingly, yeasts have been used as hosts for the expres­ sion of heterologous genes, because yeasts and higher eukaryotes share many metabolic pathways. One of these is the asparagine-linked

Journal

Annual Review of BiochemistryAnnual Reviews

Published: Jul 1, 1987

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