PERSPECTIVES AND SUMMARY Chimeras often found themselves in important posItions. Centaurs (man/ horse) were magical shape-shifters who taught the Hellenic gods . Mermaids (woman/fish) were regarded so highly that, up to the 1 9th century, English law claimed "all mermaids found in British waters" for the Crown . Surely no less important roles are acknowledged in modem times for glycoproteins 0066-4154/87/0701-0915$02.00 KUKURUZINSKA, BERGH, & JACKSON (sugar/protein). The diverse processes in which they are involved include: cell-cell recognition, hormone-receptor binding, interactions between microÂ organisms and their hosts, protein targeting, malignant transformation, and phagocytosis. The role of carbohydrate in these phenomena has been the subject of elaborate investigations, primarily conducted using mammalian and avian systems (1,2). The inherent complexity of these systems, however, has limited experimental approach. Within the last decade, investigators have begun to recognize an alternative in the yeast systems, which offer straightforÂ ward genetics, standard biochemical approaches, and ease of manipulation. It is feasible to isolate mutants, to clone genes, and to disrupt them to determine their essentiality. Increasingly, yeasts have been used as hosts for the expresÂ sion of heterologous genes, because yeasts and higher eukaryotes share many metabolic pathways. One of these is the asparagine-linked
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1987
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera